Unveiling the Potential of Natural Resources-Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies.

Malaria kills millions of people annually, and it is one of the major causes of preventable mortality in the world. Of the different plasmodium species that induce malaria, Plasmodium falciparum and Plasmodium vivax account for the most severe form of malarial disease in humans. This review focuses on understanding preventive measures, mutation-based disease evolution, malaria-related biomarkers, and potential plant bioactive components for the treatment and management of malaria.

Phytomedicine in Disease Management: In-Silico Analysis of the Binding Affinity of Artesunate and Azadirachtin for Malaria Treatment.

In the rural communities of sub-Saharan African (sSA) countries, malaria is being managed using phytocompounds. Artesunate is reported to inhibit Gephyrin E, a central, multi-domain scaffolding protein of inhibitory post-synapses. Neem plant and its metabolites like azadirachtin are being indicated for management of malaria by traditional healers.

Evaluation of the Anti-Plasmodial potential of Latex in mice infected with .

Current artemisinin-based combination therapy (ACT) regimen for the treatment of malaria is effective, but cases of malaria parasite's resistance to existing antimalarial drugs is worrisome. This necessitates the development of new, safe, effective and affordable chemotherapy. We describe protocols for each step involved in the Anti-Plasmodial evaluation of latex in mice infected with .

In-vivo anti-plasmodial activity of phosphate buffer extract of Calotropis procera latex in mice infected with Plasmodium berghei.

Ethnopharmacological Relevance: Malaria is a global health problem with the greatest burden in sub-Saharan Africa (sSA). The resistance to available antimalarial agents necessitate for the development of new and safe drugs for which medicinal plants provides credible alternative sources for discovering new and cheap therapeutic agents. Calotropis procera is used in several folk or traditional medicines for the treatment of various diseases across different regions of the world.

Anti-sickling Efficacy of Methanolic Extract of Medicinal Plants from Gwagwalada, Nigeria.

Background: Medicinal plants are used in many rural communities in Abuja for the management of Sickle Cell Disease (SCD) without any scientific evidence to validate the effectiveness of such phytomedicines. The aim of this study is to investigate the anti-sickling efficacy of some medicinal plants used by rural communities in Gwagwalada, Abuja, for management of SCD.

Methods: Phytochemical screening and mineral analysis were carried out.