[Age-dependent changes in phospholipid content and neutral lipid contents in aging].

Oxidative processes and lipid metabolism in young (3-4 months) and old (25-28 months) were studied. The increase of the rate of reactions of free radical oxidation of lipids (hydroperoxides, and malondialdehyde) and the accumulation of products of oxidative modification of proteins was recorded in mitochondrial fraction of rat brain. The accumulation of nitric oxide in the mitochondria and the oxidation products leads to the development of oxidative stress.

[Effect of cysteine lithium salt on lipid peroxidation in the model of dopaminergic system disorder].

The antioxidant activity of a newly synthesized compound, cysteine lithium salt, was discovered using methyl oleate oxidation model of dopaminergic system disorder. Experimental data show that injection of the synthesized compound in animals with experimentally induced L-DOPA brings to normalization effect conditioned by inhibiting free radical reactions in the nuclear and mitochondrial fractions of brain cells. Antioxidant effect of the synthesized compound is related to its chemical structure that contains cysteine--an agent involved in the biosynthesis of glutathione, which is a component of glutathione peroxidase and glutathione reductase enzymes participating in the antiradical protection system.

[Pyromecaine--a new anti-arrhythmia preparation improving myocardial blood supply].

Pyromecaine is a local anesthetic used for surface anesthesia. Its marked antiarrhythmic activity has been established in various models of experimental cardiac arrhythmia in doses of 0.1-2.

[Relation between extra- and intracardiac anti-strophanthin properties of anti-arrhythmic agents].

Animal experiments have shown that beta-adrenoblockers have the most marked antistrophanthin properties while antiarrhythmic agents with locally anesthetic attributes are less active. All the substances studied have proved to be ineffective on the cellular model of strophanthin arrhythmia. The data obtained suggest that the antiarrhythmic effect of the substances under study including beta-adrenoblockers is exercised on the level of the receptor apparatus of the postsynaptic membrane.

[Anti-arrhythmia properties of pyromecaine].

Antiarrhythmic activity of the local anesthetic pyromecaine has been studied. The drug has been shown to eliminate flutter of the atria provoked by electrical stimulation of the myocardium, by aconitin, strophanthine and barium chloride. It prevents ventricular fibrillation arising due to calcium chloride poisoning.

[Comparison of the anti-arrhythmia and local anesthetizing actions of some substances].

A comparison of antiarrhythmic activity of substances (stimulation of the heart with electric current and measuring the duration of the refractory peroid) as against their local anesthetic properties (the eye cornea of the rabbit and the ischiatic nerve of the frog) proved the existence of a close correlation between the ability of substances to abolish arrhythmia, caused by an electric stimulation of the heart, and their capacity to produce a conduction anesthesia in the ischiatic nerve of a decapitated frog.