Hafnium-Based Chiral 2D Organic-Inorganic Hybrid Metal Halides: Engineering Polarity and Nonlinear Optical Properties via -Substituent Effects.

Two-dimensional (2D) organic-inorganic hybrid metal halides (OIMHs), characterized by noncentrosymmetric structures arising from the incorporation of chiral organic molecules that break inversion symmetry, have attracted significant attention. Particularly, chiral-polar 2D OIMHs offer a unique platform for multifunctional applications, as the coexistence of chirality and polarity enables the simultaneous manifestation of distinct properties such as nonlinear optical (NLO) effects, circular dichroism (CD), and ferroelectricity. In this study, we report the first synthesis of hafnium (Hf)-based chiral 2D OIMHs, achieved through the strategic incorporation of -substituents on the benzene ring of chiral organic components.

Multifaceted Natural Language Processing Task-Based Evaluation of Bidirectional Encoder Representations From Transformers Models for Bilingual (Korean and English) Clinical Notes: Algorithm Development and Validation.

Background: The bidirectional encoder representations from transformers (BERT) model has attracted considerable attention in clinical applications, such as patient classification and disease prediction. However, current studies have typically progressed to application development without a thorough assessment of the model's comprehension of clinical context. Furthermore, limited comparative studies have been conducted on BERT models using medical documents from non-English-speaking countries.

Bi(SO)F·HO and Bi(SO)(NO)·3HO: Chemical Substitution-Induced Birefringence Enhancement in Bismuth Sulfates.

Two new Bi(III)-based sulfates, namely, Bi(SO)F·HO (BSOF) and Bi(SO)(NO)·3HO (BSNO), have been successfully synthesized through aliovalent replacement of partial [SO] groups with F and [NO] anions, respectively, in the parent structure of Bi(SO). Such chemical replacement altered the coordination environment of Bi cations, facilitating changes in the structure and optical properties. Notably, the birefringence values of BSOF and BSNO are found to be 4.

The Pellino1-PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function.

CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediator for innate immunity.

Analysis of Platen Superheater Tube Degradation in Thermal Power Plants via Destructive/Non-Destructive Characteristic Evaluation.

Coal-fired power plants operating under Korea's standard supercritical pressure operate in a high-temperature environment, with steam temperatures reaching 540 °C. A standard coal-fired power plant has a 30-year design life, and lifespan diagnosis is performed on facilities that have operated for more than 100,000 h or 20 years. Visual inspection, thickness measurements, and hardness measurements in the field are used to assess the degree of material degradation at the time of diagnosis.

Model-based autonomous plate defects visualization method for quantitative wall-thinning estimation.

The visualization of the wall thinning of plate-like structures using scanning laser Doppler vibrometry (SLDV) is a promising method in nondestructive evaluation using laser ultrasonics. In particular, the Lamb-wave-based SLDV method that uses continuous excitation exhibits excellent performance for the estimation of the wall thinning of plates. Currently, plate thickness is quantitatively evaluated based on wavenumber analysis using measured signals.

Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells.

The homeostatic balance between effector T cells and regulatory T cells (Tregs) is crucial for adaptive immunity; however, epigenetic programs that inhibit phosphorylation to regulate Treg development, peripheral expression, and suppressive activity are elusive. Here, we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways, including the T-cell receptor and IL-2R pathways, and localizes at the cell membrane. Deletion of Ssu72 in T cells disrupts CD4 T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ, which induce CD4 T-cell activation and differentiation into effector cell lineages.

Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease.

Background: Endocrine complications such as impaired growth, delayed puberty, and low bone mineral density (BMD) can be associated with inflammatory bowel disease (IBD) in children and adolescents. This study was performed to investigate the frequency, characteristics, and outcomes of endocrine complications of IBD in children and adolescents.

Methods: This study included 127 patients with IBD diagnosed before 18 years of age [117 with Crohn disease (CD) and 10 with ulcerative colitis (UC)].

Living donor liver retransplantation for primary non-function of liver graft following multivisceral transplantation in a pediatric patient.

Multivisceral organ transplantation (MVOT) includes transplantation of three or more abdominal organs, generally including the small bowel, duodenum, stomach, liver, pancreas, and colon. We here presented the detailed procedures of repeat living donor liver transplantation for primary non-function of the first liver graft following MVOT in a pediatric patient. A 6-year-old girl with chronic intestinal pseudo-obstruction underwent MVOT with 5-year-old donor organs.

Predominance of the c.648G > T G6PC gene mutation and late complications in Korean patients with glycogen storage disease type Ia.

Background: Glycogen storage disease (GSD) Ia, caused by mutations in the glucose-6-phosphatase (G6PC) gene, is characterized by hepatomegaly, hypoglycemia, lactic acidosis, dyslipidemia, and hyperuricemia. This study aimed to investigate clinical and molecular features and late complications in Korean patients with GSD Ia.

Results: Fifty-four Korean patients (33 males and 21 females) from 47 unrelated families, who were diagnosed with GSD Ia, based on genetic and biochemical data, between 1999 and 2017, were included in this study.

Wedged-patch venoplasty of the left liver graft portal vein for size matching in pediatric living donor liver transplantation.

Portal vein (PV) size matching between recipient and liver graft is important in preventing anastomotic stenosis in living donor liver transplantation (LDLT). In right liver grafts, the diameter of graft PV is usually >10 mm. Thus, PV size matching does not become critical in adult recipients.

On-Line Monitoring of Pipe Wall Thinning by a High Temperature Ultrasonic Waveguide System at the Flow Accelerated Corrosion Proof Facility.

Pipe wall thinning and leakage due to flow accelerated corrosion (FAC) are important safety concerns for nuclear power plants. A shear horizontal ultrasonic pitch/catch technique was developed for the accurate monitoring of the pipe wall-thickness. A solid couplant should be used to ensure high quality ultrasonic signals for a long operation time at an elevated temperature.

Magnetostrictive Guided Wave Technique Verification for Detection and Monitoring Defects in the Pipe Weld.

During inspection of piping in nuclear power plants or other industries, it is difficult to implement conventional nondestructive techniques due to limited accessibility or obstacles such as pipes with insulation, pipes buried underground, structural complexity, or radiation environments. In addition, since the defects mainly occur in the weld region or support area, it is not easy to separate defect signals from those of structural components. To solve these problems, we developed a technique to detect and monitor the formation and growth of defects, using a magnetostrictive guided wave sensor.

Conditional random fields for clinical named entity recognition: A comparative study using Korean clinical texts.

Background: This study demonstrates clinical named entity recognition (NER) methods on the clinical texts of rheumatism patients in South Korea. Despite the recent increase in the adoption rate of the electronic health record (EHR) system in global health institutions, health information technologies for handling and acquisition of information from numerous unstructured texts in the EHR system are still in their developing stages. The aim of this study is to verify the conventional named entity recognition (NER) methods, namely dictionary-lookup-based string matching and conditional random fields (CRFs).

Developing Methodologies to Find Abbreviated Laboratory Test Names in Narrative Clinical Documents by Generating High Quality Q-Grams.

Laboratory test names are used as basic information to diagnose diseases. However, this kind of medical information is usually written in a natural language. To find this information, lexicon based methods have been good solutions but they cannot find terms that do not have abbreviated expressions, such as "neuts" that means "neutrophils".

Variant meso-Rex bypass with transposition of abdominal autogenous vein for the management of idiopathic extrahepatic portal vein obstruction: a retrospective observational study.

Background: The aim of this study was to evaluate whether variant meso-Rex bypass with transposition of abdominal autogenous vein can be used as an alternative treatment modality for selected patients with symptomatic extrahepatic portal vein obstruction.

Methods: This was a retrospective review of six consecutive patients who received this alternative procedure for the treatment of symptomatic portal hypertension secondary to idiopathic extrahepatic portal vein obstruction. Their clinical characteristics, operative procedures and outcomes were analyzed retrospectively.

Use of meso-Rex shunt with transposition of the coronary vein for the management of extrahepatic portal vein obstruction.

The meso-Rex shunt is used to safely and effectively treat patients with portal hypertension due to extrahepatic portal vein obstruction. In the standard meso-Rex shunt technique, the patient's own internal jugular vein is used as a vascular autograft. Inevitably, such a procedure requires neck exploration and sacrifice of the internal jugular vein.

Management of late-onset portal vein complications in pediatric living-donor liver transplantation.

The purpose of this study was to evaluate retrospectively the results of PTA for late-onset PV complications after pediatric LDLT and to assess whether a meso-Rex shunt is a viable option for treating restenosis of the PV after PTA in selected cases. Seventy-five children who underwent adult-to-child LDLT were included in this study, and there were six late-onset PV complications (8.0%).

Identification of novel ATP7B gene mutations and their functional roles in Korean patients with Wilson disease.

Wilson disease (WND), an autosomal recessive disorder of copper transport, is characterized by excessive accumulation of intracellular copper in liver and extrahepatic tissues because of impaired biliary copper excretion and disturbed incorporation of copper into ceruloplasmin. Hepatic cirrhosis and neuronal degeneration are the major symptoms of WND, and mutations in the ATP7B gene are associated with WND. We have identified 28 different mutations in the ATP7B gene, including six novel variations, in 120 unrelated Korean patients with WND.

Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe.

Serious complications have occurred in a considerable proportion of living donors of liver transplants, but data from a single high-volume center has rarely been available. We analyzed the medical records of donors and recipients of the first 1,000 living donor liver transplants, performed at Asan Medical Center from December 1994 to June 2005, with a focus on donor safety. There were 107 pediatric and 893 adult transplants.