Ethosome Containing Ceramide as a Skin Carrier of Active Ingredients.

Background: Numerous formulations have been utilized in the cosmetic and pharmaceutical industries to effectively deliver bioactive ingredients.

Methods: We selected a well-known liposomal formulation of bilayer lipid vesicles composed of ceramide NP. Ethosomes contain hydrophilic vanillic acid or lipophilic α-bisabolol, and their physicochemical properties were evaluated.

Preparation and Evaluation of Pluronic Lecithin Organogels in Cosmetics.

This study was performed to investigate the application of pluronic lecithin organogel (PLO gel) in cosmetics as a topical drug delivery system. PLO gel was known as transdermal drug delivery systems. It has a very interesting system, owing to their biocompatibility; their amphiphilic nature, facilitating dissolution of various drug classes; and their permeation enhancement properties.

Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells.

Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles in hair growth and regeneration. Myristoleic acid (MA) increases Wnt reporter activity in DPCs.

Determination of Required HLB Values for Fruit Oil, Peel Oil, Horse Fat and Seed Oil.

In the present study, the required hydrophilic lipophilic balance (HLB) values of fruit oil (CUFO), peel oil (CUPO), horse fat (HF), and seed oil were determined empirically by preparing oil-in-water (o/w) emulsions. Lipophilic and hydrophilic surfactants were prepared in various ratios in o/w emulsion. The droplet size of the emulsion was measured using a particle size analyzer, and the turbidity was measured using a turbidity meter and a ultraviolet (UV)-vis spectrophotometer.

Protective effect of Cornus walteri Wangerin leaf against UVB irradiation induced photoaging in human reconstituted skin.

Ethnopharmacological Relevance: Cornus walteri Wangerin has been used in oriental traditional medicine for the treatment of antidiarrheal and inflammation.

Aim Of The Study: The efficacy of Cornus walteri Wangerin on skin anti-photoaging was investigated.

Materials And Methods: Hydrolyzed Cornus walteri Wangerin leaf was tested for the anti-photoaging effects against ultraviolet B (UVB)-induced matrix metalloproteinase (MMP)-1, pro-inflammatory cytokines using human reconstituted skin (KeraSkin™-FT) and also tested for elastase activity in vitro.

Visible-to-near IR quantum dot-based hypermulticolor high-content screening of herbal medicines for the efficacy monitoring of hair growth promotion and hair loss inhibition.

There is a growing interest in alopecia prevention strategies, as the number of alopecia patients is increasing. We examine the efficacy of herbal medicine for hair growth promotion/hair loss inhibition in two cell lines via Western blot and high-content screening (HCS). Nine herbal extracts were obtained from three different herbal medicine mixtures using 3 different extraction methods.

Photoprotective effects of methoxycinnamidopropyl polysilsesquioxane.

A new sunscreen ingredient, methoxycinnamidopropyl polysilsesquioxane (MCP-PSQ), which contains an UV-absorbing p-methoxycinnamoyl group, has been developed synthetically and evaluated using in vitro and in vivo approaches. Previous studies revealed that MCP-PSQ has a raising or boosting effect on the sun protection factor (SPF) of other sunscreen agents. In this study, we demonstrated that MCP-PSQ, an organic/inorganic hybrid compound, has photoprotective effects for human fibroblasts, and for hairless mouse and human skin.

MKK6 increases the melanocyte dendricity through the regulation of Rho family GTPases.

Background: Melanocyte dendrites serve as the principal conduit for melanosome transfer. The dendrite formation requires actin polymerization mediated by Rho family GTPases including RhoA, Rac1 and Cdc42.

Objective: The aim of this study is to investigate and explore the involvement of p38 MAPK in melanocyte dendrite formation.

Anti-inflammatory effects of YeongyoSeungma-tang.

Ethnopharmacological Relevance: YeongyoSeungma-tang which includes Fructus Forsythia, has been used in oriental traditional medicine for treatment of early smallpox and atopic dermatitis.

Aim Of The Study: YeongyoSeungma-tang was carried out to investigate for anti-inflammatory effects.

Materials And Methods: YeongyoSeungma-tang was tested for anti-inflammatory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor alpha (TNF-alpha) releases as well as nuclear factor kappa B (NF-kappaB) expression using RAW264.

Antioxidant and antimelanogenic activities of polyamine conjugates from corn bran and related hydroxycinnamic acids.

The antioxidant activity of three major polyamine conjugates, N,N'-dicoumaroyl-putrescine (DCP), N-p-coumaroyl-N'-feruloylputrescine (CFP), and N,N'-diferuloyl-putrescine (DFP) isolated from corn bran, and their related hydroxycinnamic acids, p-coumaric acid and ferulic acid, were evaluated by three antioxidant in vitro assay systems, including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and superoxide and hydroxyl radicals generated by enzymatic and nonenzymatic reactions. Additionally, five phenolic compounds were evaluated for melanogenesis inhibitory activity using mushroom tyrosinase and B16 melanoma cells. Most of the phenolic compounds significantly scavenged DPPH, superoxide, and hydroxyl radicals in a dose-dependent manner.