Publications by authors named "Kyung-Sun Park"

Background: Left ventricular (LV) diastolic dysfunction is frequently observed in patients with end-stage kidney disease (ESKD) and a significant risk factor for the development of cardiovascular events in those patients. We hypothesized that the ratio of early diastolic peak mitral flow velocity to early mitral annulus velocity (E/e' ratio), the widely used non-invasive LV diastolic dysfunction index, would show improvements following kidney transplantation (KT).

Materials And Methods: A total of 192 KT recipients who underwent echocardiography before KT and 2 years after KT were included this analysis.

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Background: Type 2B von Willebrand disease (VWD) is a less common subtype and is difficult to diagnose. This case report and literature review highlights a rare neonatal onset of type 2B VWD initially misdiagnosed as neonatal alloimmune thrombocytopenia (NAIT).

Methods: The neonate presented with severe thrombocytopenia and was unresponsive to NAIT treatments.

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Article Synopsis
  • The study aimed to assess how smoking status affects hidden coronary artery disease (atherosclerosis) in people without symptoms, using advanced imaging technology (CCTA).
  • Out of 9,285 participants examined, current smokers had notably higher risks of various forms of arterial plaque and obstructive coronary artery disease compared to never smokers, while former smokers mainly showed increased risk for non-calcified plaque.
  • The findings highlight that current smoking is strongly linked to early signs of heart disease, and former smoking also raises cardiovascular risk due to more non-calcified plaques.
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In Asian patients with atrial fibrillation (AF) and end-stage renal disease (ESRD) undergoing dialysis, the use of direct oral anticoagulants (DOACs) remains debatable. From the national health insurance claims data in South Korea, we included 425 new users of OAC among patients with non-valvular AF and ESRD undergoing dialysis between 2013 and 2020. Patients were categorized into DOAC (n = 106) and warfarin group (n = 319).

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Background: Droplet digital (dd)PCR is a new-generation PCR technique with high precision and sensitivity; however, the positive and negative droplets are not always effectively separated because of the "rain" phenomenon. We aimed to develop a practical optimization and evaluation process for the ddPCR assay and to apply it to the detection of V600E in fine-needle aspiration (FNA) specimens of thyroid nodules, as an example.

Methods: We optimized seven ddPCR parameters that can affect "rain.

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Coupling of spin and charge currents to structural chirality in non-magnetic materials, known as chirality-induced spin selectivity, is promising for application in spintronic devices at room temperature. Although the chirality-induced spin selectivity effect has been identified in various chiral materials, its Onsager reciprocal process, the inverse chirality-induced spin selectivity effect, remains unexplored. Here we report the observation of the inverse chirality-induced spin selectivity effect in chiral assemblies of π-conjugated polymers.

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Background: Differentiating bacterial and viral meningitis is crucial, and this study explored the potential of mean platelet volume (MPV) as a marker for differentiation.

Methods: Blood samples were collected from patients with central nerve system related manifestations, and MPV was tested. Cerebrospinal fluid samples were obtained and bacterial culture and the FilmArray ME panel were performed.

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Understanding the solution-state aggregate structure and the consequent hierarchical assembly of conjugated polymers is crucial for controlling multiscale morphologies during solid thin-film deposition and the resultant electronic properties. However, it remains challenging to comprehend detailed solution aggregate structures of conjugated polymers, let alone their chiral assembly due to the complex aggregation behavior. Herein, we present solution-state aggregate structures and their impact on hierarchical chiral helical assembly using an achiral diketopyrrolopyrrole-quaterthiophene (DPP-T4) copolymer and its two close structural analogues wherein the bithiophene is functionalized with methyl groups (DPP-T2M2) or fluorine atoms (DPP-T2F2).

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Article Synopsis
  • - This study investigated the link between food insecurity and chronic diseases in older adults in South Korea, comparing findings with data from the U.S.
  • - Data from the Korea National Health and Nutrition Examination Survey revealed no significant relationship between food insecurity and hypertension, diabetes, or chronic kidney disease among older South Koreans, unlike the U.S. data which showed food insecurity increased hypertension risks.
  • - The findings highlight differing impacts of food insecurity on health in South Korea and the U.S., suggesting more research is necessary to understand these variations.
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This study sought to evaluate the association between the degree of hypertension and subclinical coronary atherosclerosis in asymptomatic subjects with and without diabetes mellitus (DM). We retrospectively analyzed 7,352 asymptomatic subjects (mean age 52.8 ± 7.

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Keratinocytes are pivotal cells in the pathogenesis of atopic dermatitis (AD) as much as Th2 cells. In this sense, regulation of pro-inflammatory features of keratinocytes might be useful for AD patients. P2X7R-mediated activation of NLRP3 inflammasome (N3I) in keratinocytes and myeloid cells plays crucial roles in AD.

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Bottlebrush polymers are a class of semiflexible, hierarchical macromolecules with unique potential for shape-, architecture-, and composition-based structure-property design. It is now well-established that in dilute to semidilute solution, bottlebrush homopolymers adopt a wormlike conformation, which decreases in extension (persistence length) as the concentration and molecular overlap increase. By comparison, the solution phase self-assembly of bottlebrush diblock copolymers (BBCP) in a good solvent remains poorly understood, despite critical relevance for solution processing of ordered phases and photonic crystals.

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Introduction: Malakoplakia is a rare pseudotumor that arises in the context of recurrent infections, particularly in immunocompromised states. We report a case of renal allograft parenchymal malakoplakia.

Case Report: A 59-year-old woman successfully received a cadaveric renal transplant in June 2018.

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Tuning structures of solution-state aggregation and aggregation-mediated assembly pathways of conjugated polymers is crucial for optimizing their solid-state morphology and charge-transport property. However, it remains challenging to unravel and control the exact structures of solution aggregates, let alone to modulate assembly pathways in a controlled fashion. Herein, aggregate structures of an isoindigo-bithiophene-based polymer (PII-2T) are modulated by tuning selectivity of the solvent toward the side chain versus the backbone, which leads to three distinct assembly pathways: direct crystallization from side-chain-associated amorphous aggregates, chiral liquid crystal (LC)-mediated assembly from semicrystalline aggregates with side-chain and backbone stacking, and random agglomeration from backbone-stacked semicrystalline aggregates.

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Article Synopsis
  • * The analysis divided participants into married and unmarried categories, with no significant differences found in the prevalence of coronary plaque or significant stenosis based on marital status after adjusting for cardiovascular risk factors.
  • * Ultimately, the findings suggest that being unmarried does not correlate with an increased risk of subclinical coronary atherosclerosis in this population.
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Development of graphene-organic hybrid electronics is one of the most promising directions for next-generation electronic materials. However, it remains challenging to understand the graphene-organic semiconductor interactions right at the interface, which is key to designing hybrid electronics. Herein, we study the influence of graphene on the multiscale morphology of solution-processed monolayers of conjugated polymers (PII-2T, DPP-BTz, DPP2T-TT, and DPP-T-TMS).

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Intimately connected to the rule of life, chirality remains a long-time fascination in biology, chemistry, physics and materials science. Chiral structures, e.g.

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Background And Aims: There is limited data on the association between serum phosphorus concentration (SPC) and subclinical coronary atherosclerosis in low-risk asymptomatic subjects without kidney dysfunction.

Materials And Methods: We retrospectively analyzed 1,636 Korean individuals (mean age 52.6 ± 7.

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Amyloid β (Aβ) and/or ATP activate the NLRP3 inflammasome (N3I) P2X7R in microglia, which is crucial in neuroinflammation in Alzheimer's disease (AD). Due to polymorphisms, subtypes, and ubiquitous expression of P2X7R, inhibition of P2X7R has not been effective for AD. We first report that taurodeoxycholate (TDCA), a GPCR19 ligand, inhibited the priming phase of N3I activation, suppressed P2X7R expression and P2X7R-mediated Ca mobilization and N3I oligomerization, which is essential for production of IL-1β/IL-18 by microglia.

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Introduction: The detection of malignant cells in body fluids (BF) with an automated hematology analyzer has been proposed as an alternative to morphological examination owing to its various advantages; however, its limitations have also been highlighted. In this study, we devised a practical algorithm to screen for malignant cells in BFs using an automated hematology analyzer.

Methods: A total of 558 BF samples, including 232 cerebrospinal fluid (CSF) samples and 326 non-CSF samples, were consecutively collected.

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Background And Aims: There are limited data regarding the association between lipoprotein(a) (Lp[a]) and subclinical coronary atherosclerosis. This study investigated the association between Lp(a) and subclinical coronary atherosclerosis detected by coronary computed tomographic angiography (CCTA) in an asymptomatic population.

Methods: We retrospectively analyzed 7201 asymptomatic individuals (mean age 54.

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In this study, two different approaches were applied in the analysis of the gene. One was analyzed based on patients with Pompe disease, and the other was analyzed based on genomic data from unaffected carriers in a general population genetic database. For this, variants in Korean and Japanese patients reported in previous studies and in patients reported in the Pompe disease variant database were analyzed as a model.

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