Publications by authors named "Kyung-Hong Kim"
The aim of the current study was to investigate the effects of glucosamine (GlcN) on septic lethality and sepsis-induced inflammation using animal models of mice and zebrafish. GlcN pretreatment improved survival in the cecal ligation and puncture (CLP)-induced sepsis mouse model and attenuated lipopolysaccharide (LPS)-induced septic lung injury and systemic inflammation. GlcN suppressed LPS-induced M1-specific but not M2-specific gene expression.
View Article and Find Full Text PDFWe investigated the regulatory effect of glucosamine (GlcN) for the production of nitric oxide (NO) and expression of inducible NO synthase (iNOS) under various glucose conditions in macrophage cells. At normal glucose concentrations, GlcN dose dependently increased LPS-stimulated production of NO/iNOS. However, GlcN suppressed NO/iNOS production under high glucose culture conditions.
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- The study investigated the anti-inflammatory effects of three synthesized tryptamine hybrid compounds (HBU-375, HBU-376, and HBU-379) focusing on their ability to inhibit inflammatory responses in BV2 cells.
- HBU-376 and HBU-375 effectively reduced nitric oxide (NO) generation induced by LPS, but HBU-376 showed less cellular toxicity, suggesting it could be a better candidate for therapeutic use.
- The findings indicate that HBU-376 works by inhibiting key inflammatory pathways, specifically NF-κB activation and the expression of various inflammatory genes, positioning it as a potential treatment for neurological inflammatory diseases.