Publications by authors named "Kyung-Deuk Cho"
Article Synopsis
- Radioimmunotherapy (RIT) is a targeted therapy for non-Hodgkin lymphomas, but the role of the biomarker HIF-1α in this context is not well understood, despite the use of Atorvastatin (ATV) in combination with chemotherapy.
- In experiments with Raji xenograft mouse models, it was found that ATV enhances the effectiveness of rituximab (I-RTX) by increasing its uptake and therapeutic impact, while also downregulating HIF-1α through the action of miR-346.
- The results indicate that combining ATV with I-RTX can improve treatment outcomes for patients who are poorly responsive or exhibit radio-resistance in non-Hodgkin lymphoma
Platelet-activating factor (PAF) promotes tumour metastasis via activation of the transcription factor nuclear factor-κB (NF-κB). We here investigated the role of the protein kinase CK2 (formerly Casein Kinase 2 or II) in PAF-induced NF-κB activation and tumour metastasis, given that PAF has been reported to increase CK2 activity, and that CK2 plays a key role in NF-κB activation. PAF increased CK2 activity, phosphorylation and protein expression in vivo as well as in vitro.
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