Whitening and moisturizing enhancing effects of three-dimensional human adipose-derived mesenchymal stem cell-conditioned medium-containing cream.

Background: High-functional cosmetic products combined with the concept of "treatment" cosmetics are being introduced to the market. Cosmetic products containing a skin-derived microbiome, a three-dimensional (3D) stem cell culture medium, and low-molecular-weight collagen are being introduced, and these products are leading the cosmeceutical market. We aimed to confirm the potential of a 3D stem cell culture medium-containing cream as a skin-whitening and moisturizing product.

Identification of a novel trait associated with phytotoxicity of an insecticide etofenprox in soybean.

Synthetic insecticides are widely used to control pests in various crop fields. Especially in soybean [ (L.) Merr.

Enhancing the recruitment of postgraduate researchers from diverse countries: managing the application process.

International students form an important element of most universities' internationalisation strategies, especially for research and the recruitment of high calibre PhD students (PGRs). Despite the numerous studies of PGRs' post-arrival experiences, there is a major dearth of research into their pre-arrival, application experiences. Given the worldwide competition for high calibre PGRs, along with impact posed by the Covid-19 pandemic and by Brexit for the UK, it is vital for universities to ensure that factors clearly under their control, such as the information on their websites and the way they communicate, are as informative and helpful as possible.

Hybrid neural network with cost-sensitive support vector machine for class-imbalanced multimodal data.

Although deep learning exhibits advantages in various applications involving multimodal data, it cannot effectively solve the class-imbalance problem. Herein, we propose a hybrid neural network with a cost-sensitive support vector machine (hybrid NN-CSSVM) for class-imbalanced multimodal data. We used a fused multiple-network structure obtained by extracting the features of different modality data, and used cost-sensitive support vector machines (SVMs) as a classifier.

Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy.

Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between these 2 Aβ biomarkers. We conducted a comparison of CSF Aβ1-42 level, amyloid PET, and autopsy findings in a case with progressive supranuclear palsy in which biomarker acquisition and postmortem pathologic examination were conducted almost at the same time.

Diffusion-weighted imaging negative M232R familial Creutzfeldt-Jakob disease.

The familial Creutzfeldt-Jakob disease (fCJD) usually has similar clinical and neuroimaging features as sporadic CJD (sCJD). A 57-year-old man presented with a four-month history of rapidly progressive dementia (RPD). Laboratory tests for RPD were all normal.

Tunable Emission of Bluish Zn-Cu-Ga-S Quantum Dots by Mn Doping and Their Electroluminescence.

On the basis of bluish-emitting double-shelled quantum dots (QDs) of Zn-Cu-Ga-S (ZCGS)/ZnS/ZnS, Mn doping into ZCGS host with different Mn/Cu concentrations is implemented via surface adsorption and lattice diffusion. The resulting double-shelled Mn-doped ZCGS (ZCGS/Mn) QDs exhibit a distinct MnT-A emission as a consequence of effective lattice incorporation simultaneously with host intragap states-involving emissions of free-to-bound and donor-acceptor pair recombinations. The relative contribution of Mn emission to the overall photoluminescence (PL) is consistently proportional to its concentration, resulting in tunable PL from bluish, white, to reddish white.

Electroluminescence from two I-III-VI quantum dots of A-Ga-S (A=Cu, Ag).

Together with III-V InP, chalcopyrite I-III-VI metal chalcogenides particularly with the compositions of A-B-S (A=Cu, Ag, B=In, Ga) are regarded as an emerging non-Cd class for synthesis of visible-emitting colloidal quantum dots (QDs) and the following fabrication of QD-light-emitting diodes (QLEDs). To date, the composition of I-III-VI QDs which were exploited for QLED fabrication remains highly limited, with most devices demonstrated from Cu-In-S-based ones. Herein, we explore the synthesis of two Ga-based I-III-VI QDs of Ag-Ga-S (AGS) and Cu-Ga-S (CGS) QDs and their application to QLED fabrication.

Clinical Implications of Basilar Artery Plaques in the Pontine Infarction with Normal Basilar Angiogram: A High-Resolution Magnetic Resonance Imaging Study.

Background: Using high-resolution magnetic resonance imaging (HR-MRI), we investigated the impact of basilar artery plaques that were not detected by magnetic resonance angiography (MRA) on the functional outcomes of patients with acute pontine infarction.

Methods: A total of 40 patients with acute pontine infarction and normal basilar findings on MRA prospectively underwent HR-MRI for detection of basilar artery plaques. A relevant plaque was defined as one on the dorsal side of basilar artery, the same side of the ischemic lesion, and the same axial slices of the ischemic lesion.

Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.

Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle-like cells expressing α-smooth muscle actin (α-SMA) via transforming growth factor-β1/Smad2- and RhoA/Rho kinase-dependent mechanisms. 3-Hydroxy-3-methylglutaryl- coenzyme A reductase inhibitors (statins) have been known to have beneficial effects in the treatment of cardiovascular diseases. In the present study, we examined the effects of simvastatin on the SPC-induced α-SMA expression and Smad2 phosphorylation in hASCs.

Comparison of mesenchymal-like stem/progenitor cells derived from supernumerary teeth with stem cells from human exfoliated deciduous teeth.

Aims: Dental tissue has been the focus of attention as an easily accessible postnatal tissue source of high-quality stem cells. Since the first report on the dental pulp stem cells (DPSCs) from permanent third molar teeth, stem cells from human exfoliated deciduous teeth (SHED) were identified as a population distinct from DPSCs. In this study, we compared DPSCs from supernumerary teeth and SHED in three age- and sex-matched patients.

Synovial fluid of patients with rheumatoid arthritis induces alpha-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-beta1-dependent mechanism.

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. Transforming growth factor-beta1 (TGF-beta1) is a secreted protein that promotes differentiation of synovial fibroblasts to alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts to repair the damaged joints. Synovial fluid from patients with RA (RA-SF) induced expression of alpha-SMA in human adipose tissue-derived mesenchymal stem cells (hASCs).

Emergency department visits: the cost of trauma centers.

Crowded emergency departments (EDs) have become a serious problem in the current U.S. healthcare system.

Lysophosphatidic acid mediates migration of human mesenchymal stem cells stimulated by synovial fluid of patients with rheumatoid arthritis.

Migration of mesenchymal stem cells plays a key role in regeneration of injured tissues. Rheumatoid arthritis (RA) is a chronic inflammatory disease and synovial fluid (SF) reportedly contains a variety of chemotactic factors. This study was undertaken to investigate the role of SF in migration of human bone marrow-derived mesenchymal stem cells (hBMSCs) and the molecular mechanism of SF-induced cell migration.