Publications by authors named "Kyung H Cho"

Anaerobic digestion (AD), which relies on a complex microbial consortium for efficient biogas generation, is a promising avenue for renewable energy production and organic waste treatment. However, understanding and optimising AD processes are challenging because of the intricate interactions within microbial communities and the impact of volatile fatty acids (VFAs) on biogas production. To address these challenges, this study proposes the application of graph convolutional networks (GCNs) to comprehensively model AD processes.

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Background: The long-term effects of early left ventricular unloading after venoarterial extracorporeal membrane oxygenation (VA-ECMO) remain unclear.

Methods: The EARLY-UNLOAD trial was a single-center, investigator-initiated, open-label, randomized clinical trial involving 116 patients with cardiogenic shock (CS) undergoing VA-ECMO. The patients were randomly assigned to undergo either early routine left ventricular unloading by transseptal left atrial cannulation within 12 hours after randomization or the conventional approach, which permitted rescue transseptal cannulation in case of an increased left ventricular afterload.

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Air-conditioning systems, composed mainly of humidity control and heat reallocation units, play a pivotal role in upholding superior air quality and human well-being across diverse environments ranging from international space stations and pharmacies to granaries and cultural relic preservation sites, and to commercial and residential buildings. The adoption of sorbent water as the working pair and low-grade renewable or waste heat in adsorption-driven air-conditioning presents a state-of-the-art solution, notably for its energy efficiency and eco-friendliness vis-à-vis conventional electricity-driven vapor compression cycles. Here, we introduce a rational π-extension strategy to engineer an ultrarobust and highly porous zirconium metal-organic framework (Zr-MOF).

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Monitoring radioactive cesium ions (Cs) in seawater is vital for environmental safety but remains challenging due to limitations in the accessibility, stability, and selectivity of traditional methods. This study presents an innovative approach that combines electrochemical voltammetry using nickel hexacyanoferrate (NiHCF) thin-film electrode with machine learning (ML) to enable accurate and portable detection of Cs. Optimizing the fabrication of NiHCF thin-film electrodes enabled the development of a robust sensor that generates cyclic voltammograms (CVs) sensitive to Cs⁺ concentrations as low as 1 ppb in synthetic seawater and 10 ppb in real seawater, with subtle changes in CV patterns caused by trace Cs⁺ effectively identified and analyzed using ML.

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Article Synopsis
  • - The study investigates the link between myocardial bridging (MB) and coronary vasospasm (CVS), aiming to see if CVS worsens outcomes for patients with MB over the long term.
  • - Researchers included 254 patients with MB, dividing them into two groups: those with CVS (168 patients) and those without (86 patients), and examined major adverse cardiovascular events (MACEs) over an average follow-up of 8.15 years.
  • - Results showed that patients with CVS experienced significantly higher rates of MACEs (35.1%) compared to those without CVS (26.7%), indicating that CVS negatively impacts the clinical outcomes of MB patients, suggesting a need for further research.
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Background: Despite increasing evidence on the benefits of statin therapy for acute myocardial infarction (AMI), differential outcomes in accordance with statin intensity have not been evaluated in patients with AMI and low-density lipoprotein cholesterol (LDL-C) levels < 55 mg/dL. Therefore, this study aimed to compare the clinical outcomes of high- and moderate-intensity statin therapy in this population.

Methods: A total of 752 participants with AMI and LDL-C levels < 55 mg/dL from a Korean nationwide multicenter observational cohort (2016-2020) were included and categorized into two groups: high-intensity statin group (n = 384) and moderate-intensity statin group (n = 368).

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Article Synopsis
  • * Results showed that during the first week, STEMI patients had a significantly higher mortality rate (4.62%) compared to NSTEMI patients (1.79%), but this trend reversed after the second week for men and the tenth week for women.
  • * The research highlights the need for further studies to develop advanced risk prediction models based on time-point mortality outcomes, as different baseline variables influenced mortality rates over time.
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Background And Objectives: Cigarette smoking is a major risk factor for atherosclerosis. Nicotine, a crucial constituent of tobacco, contributes to atherosclerosis development and progression. However, evidence of the association between nicotine and neointima formation is limited.

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  • The study evaluated the relationship between coronary artery calcium (CAC) measured using AI and coronary flow capacity (CFC) to determine if CAC could serve as a prognostic indicator for cardiovascular events.
  • Retrospective data from 289 patients who underwent PET scans showed significant negative correlations between AI-measured CAC and both stress myocardial blood flow (MBF) and CFC, with impaired CFC being more common in patients with higher CAC levels.
  • Despite a higher incidence of major cardiovascular events among those with elevated AI-CAC scores, the analysis indicated that impaired CFC and other factors like diabetes and smoking had a stronger independent association with patient outcomes than AI-CAC itself.
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  • The study investigated the effects of clopidogrel and ticagrelor on bleeding and ischemia risks in elderly East Asian patients with diabetes and acute myocardial infarction who underwent percutaneous coronary intervention.
  • It analyzed data from 838 patients over 75 years old, ultimately comparing 466 patients after matching for treatment type.
  • Findings suggested that there was no significant difference in the incidence of severe bleeding or ischemia between those treated with ticagrelor versus clopidogrel, indicating the need for larger trials to find the best antiplatelet therapy for this group.
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  • Dyslipidemia, a key risk factor for heart attacks, has shown an increase in prevalence among Korean patients from 11.1% to 17.1% between 2011 and 2020 as this study explored trends in its management.
  • Over the same period, there was a rise in statin prescriptions from 92.9% to 97.0%, with high-intensity statin use increasing dramatically and greater adoption of drugs like ezetimibe.
  • Despite improvements in managing dyslipidemia, with more patients achieving lipid targets, ongoing efforts are crucial to further lower the risk of heart-related complications.*
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  • Scientists study how nitrate moves in water to manage water quality better. They use two types of models: mechanistic models like SWAT and data-driven models that work with different data types.* -
  • Researchers tested these models at Tuckahoe Creek in Maryland and found that the data-driven deep learning model performed better than SWAT in predicting nitrate levels and water flow.* -
  • The deep learning model showed the best results in fall and winter, and it could be a better choice for monitoring water quality if we collect data frequently.*
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Groundwater salinization is a prevalent issue in coastal regions, yet accurately predicting and understanding its causal factors remains challenging due to the complexity of the groundwater system. Therefore, this study predicted groundwater salinity in multi-layered aquifers spanning the entire Mekong Delta (MD) region using machine learning (ML) models based on an in situ dataset and using three indicators (Cl, pH, and HCO). We applied nine different decision tree-based models and evaluated their prediction performances.

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Given the frequent association between freshwater plankton and water quality degradation, several predictive models have been devised to understand and estimate their dynamics. However, the significance of biotic and abiotic interactions has been overlooked. In this study, we aimed to address the importance of the interaction term in predicting plankton community dynamics by applying graph convolution embedded long short-term memory networks (GC-LSTM) models, which can incorporate interaction terms as graph signals.

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Optimal timing of revascularization for patients who presented with non-ST segment elevation myocardial infarction (NSTEMI) and severe left ventricular (LV) dysfunction is unclear. A total of 386 NSTEMI patients with severe LV dysfunction from the nationwide, multicenter, and prospective Korea Acute Myocardial Infarction Registry V (KAMIR-V) were enrolled. Severe LV dysfunction was defined as LV ejection fraction ≤ 35%.

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Article Synopsis
  • * Twenty patients were enrolled, and results after 8 months showed minimal in-stent late lumen loss (0.7 mm) and complete stent strut coverage, indicating successful healing.
  • * There were no adverse cardiovascular events reported within the same period, suggesting that the new stent design is safe and effective in treating coronary artery disease.
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Background And Objectives: Familial hypercholesterolemia (FH) increases the risk of premature cardiovascular disease through disrupted low-density lipoprotein cholesterol (LDL-C) metabolism. Although FH is a severe condition, it remains widely underdiagnosed, which can be attributed to barriers in genetic testing and a lack of awareness. This study aims to propose and evaluate a targeted screening program for FH in South Korea by integrating the General Health Screening Program (GHSP) with cascade genetic screening.

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  • Researchers studied 861 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) to understand how the timing of hospitalization affects mortality rates over two years.
  • * They found that patients who presented late (after 12 or 24 hours) had a significantly higher risk of death compared to those who arrived early, with adjusted hazard ratios confirming this increased risk.
  • * Factors such as being female, not using emergency services, and having high creatinine levels were linked to late presentation, indicating a need for better systems to minimize delays in seeking treatment.
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The distribution coefficient (K) plays a crucial role in predicting the migration behavior of radionuclides in the soil environment. However, K depends on the complexities of geological and environmental factors, and existing models often do not reflect the unique soil properties. We propose a multimodal technique to predict K values for radionuclide adsorption in soils surrounding nuclear facilities in Republic of Korea.

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Owing to its simplicity of measurement, effluent conductivity is one of the most studied factors in evaluations of desalination performance based on the ion concentrations in various ion adsorption processes such as capacitive deionization (CDI) or battery electrode deionization (BDI). However, this simple conversion from effluent conductivity to ion concentration is often incorrect, thereby necessitating a more congruent method for performing real-time measurements of effluent ion concentrations. In this study, a random forest (RF)-based artificial intelligence (AI) model was developed to address this shortcoming.

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Artificial intelligence has been employed to simulate and optimize the performance of membrane capacitive deionization (MCDI), an emerging ion separation process. However, a real-time control for optimal MCDI operation has not been investigated yet. In this study, we aimed to develop a reinforcement learning (RL)-based control model and investigate the model to find an energy-efficient MCDI operation strategy.

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The abatement of micropollutants by ozonation can be accurately calculated by measuring the exposures of molecular ozone (O) and hydroxyl radical (OH) (i.e., ∫[O]dt and ∫[OH]dt).

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The rapid and efficient quantification of Escherichia coli concentrations is crucial for monitoring water quality. Remote sensing techniques and machine learning algorithms have been used to detect E. coli in water and estimate its concentrations.

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