Publications by authors named "Kyum-Yil Kwon"
Objectives: The Huntington's Disease Quality of Life Battery for Carers (HDQoL-C) evaluates caregiver quality of life. This study aims to develop and validate the Korean version (K-HDQoL-C) to assess the burden on Korean caregivers of HD patients.
Methods: Nineteen HD caregivers (7 females, mean age 55.
Background & Aims: Gait disturbances are commonly observed in patients with neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and higher-level gait disorders, which are associated with cholinergic deficits. We conducted a systematic review and meta-analysis to investigate the effects of rivastigmine on improvement in gait.
Methods: A comprehensive literature search was conducted using Medical Subject Heading (MeSH) terms and text keywords related to gait and falls after rivastigmine treatment for neurodegenerative disorders.
Background: The age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome-wide association studies (GWASs) have investigated genetic variants determining AAO, particularly in East Asian populations.
Objectives: To identify single-nucleotide polymorphisms (SNPs) affecting AAO of PD in Korean patients.
Article Synopsis
- - The study aimed to evaluate the reliability and validity of the Korean version of the SCales for Outcomes in Parkinson's Disease-Cognition (K-SCOPA-Cog) for assessing cognition in Parkinson's disease patients in South Korea.
- - A total of 129 patients participated, and various statistical methods, including Cronbach's alpha and Spearman’s rank correlation, were employed to test the reliability and concurrent validity against established cognitive assessments.
- - Results showed that the K-SCOPA-Cog has strong reliability (Cronbach's alpha of 0.797, ICC of 0.887) and a significant correlation with other cognitive measures (MOCA-K and K-MMSE), indicating it is a valid tool for cognitive assessment in this
Clinical Characteristics and Relevance of Dizziness in Patients with Parkinson's Disease.
J Integr Neurosci
February 2024
Article Synopsis
- - This study examined the characteristics and clinical implications of dizziness in Parkinson's disease (PD) patients, involving 93 participants from July 2017 to August 2022.
- - Findings showed that 39 patients (42%) reported dizziness, predominantly presyncope, occurring several times a week, and lasting a few seconds; women were more likely to experience dizziness.
- - Dizziness in PD patients was linked to cognitive impairment and severe cardiovascular dysautonomia, emphasizing the need for clinicians to closely monitor patients who report dizziness.
Article Synopsis
- The study investigates the systemic immune-inflammatory index (SII) and its ability to predict early neurologic deterioration (END) in patients with acute ischemic stroke.
- Data were collected from 697 patients, categorized into four groups based on quartiles of SII, and monitored for END during the first week after the stroke.
- Results indicate that a higher SII correlates with increased odds of END and stroke progression, especially in patients with large artery atherosclerosis, suggesting SII as a potential independent predictor for these outcomes.
Background And Purpose: Falls are not uncommon even in patients with early stages of Parkinson's disease (PD). The aims of this study were to determine the relationships between gait parameters and falls and identify crucial gait parameters for predicting future falls in patients with de novo PD.
Methods: We prospectively recruited patients with de novo PD, and evaluated their baseline demographics, global cognitive function on the Montreal Cognitive Assessment test, and parkinsonian motor symptoms including their subtypes.
In this paper, we propose a deep-learning-based algorithm for screening neurological diseases. We proposed various examination protocols for screening neurological diseases and collected data by video-recording persons performing these protocols. We converted video data into human landmarks that capture action information with a much smaller data dimension.
View Article and Find Full Text PDFArticle Synopsis
- This study is the first prospective cohort investigation of caregiver burden in Huntington's disease (HD) in Korea, aiming to connect patient and caregiver characteristics with the stress experienced by caregivers.
- Sixty-five HD patients and 45 caregivers participated, revealing a significant correlation between higher caregiver burden and more severe patient symptoms, as assessed by the Zarit Burden Interview (ZBI-12).
- The findings highlight that the neurological status of HD patients greatly affects caregiver stress, indicating a need for improved support systems for families affected by HD in Korea and suggesting further study of the impact of disease progression on caregiver burden.
Article Synopsis
- The study aimed to explore the efficacy of plasma markers such as neurofilament light chain (NfL), phosphorylated tau (p-Tau), and total tau (t-Tau) in determining the clinical severity of Huntington's disease (HD) among Korean patients.
- Involving 67 genetically-confirmed HD patients, researchers utilized various assessment tools to evaluate motor and cognitive function and measured plasma concentrations of the biomarkers using advanced assays.
- Results indicated that NfL was significantly elevated in HD patients, particularly increasing from premanifest to manifest stages, while p-Tau levels correlated with clinical severity but t-Tau did not show notable differences among groups, suggesting NfL and p-Tau as potential biomarkers for HD severity.
Background: Complaining of dizziness is common in patients with Parkinson's disease (PD) even at the early phase of the disease. Therefore, regarding motor or non-motor symptoms, clinical implication of subjective dizziness in early Parkinsonian patients is needed to be explored.
Methods: Eighty patients diagnosed with early PD (defined by disease duration of five years or less) were retrospectively enrolled for the study.
Objective: Studies on gait and autonomic dysfunction have been insufficient so far, particularly de novo Parkinson's disease (PD). The aim of this study was to identify the association between gait dynamics and autonomic dysfunction in patients with de novo PD.
Methods: A total 38 patients with de novo PD were retrospectively included in this study.
The risk factors of mild cognitive impairment (MCI) in patients with de novo Parkinson's disease (PD) remain unclear. Therefore, the objective of this study was to compare motor and non-motor symptoms between de novo patients with PD with and without MCI. Moreover, detailed relationships between each cognitive deficit and other clinical characteristics in de novo patients with PD were investigated.
View Article and Find Full Text PDFClinicians sometimes encounter patients with Parkinson's disease complaining of dizziness in real clinical settings. We sought to identify the relationship between self-perceived dizziness and motor or non-motor symptoms, especially in Parkinsonian patients in the early stages. Eight-six patients with less than five years of Parkinson's disease duration were recruited.
View Article and Find Full Text PDFEffect of intensive olfactory training for cognitive function in patients with dementia.
Geriatr Gerontol Int
January 2022
Aim: Recent evidence has revealed an association between neurodegenerative disorders and olfactory dysfunction. However, whether olfactory training can improve cognitive impairment in patients with dementia requires further study. The present study aimed to resolve this by developing an intensive olfactory training (IOT) protocol and assessing its impact on each of the cognitive domains in patients with dementia.
View Article and Find Full Text PDFFreezing of gait (FOG) is a common occurrence in patients with Parkinson's disease (PD) that leads to significant limitations in mobility and increases risk of falls. Focused vibrotactile stimulation and cueing are two methods used to alleviate motor symptoms, including FOG, in patients with PD. While effective on their own, the effect of combining both focused vibrotactile stimulation and cueing has yet to be investigated.
View Article and Find Full Text PDFAccurate diagnosis of idiopathic normal pressure hydrocephalus is important to manage patients with idiopathic normal pressure hydrocephalus more appropriately. Based on the clinical features and brain magnetic resonance imaging findings, the idiopathic normal pressure hydrocephalus diagnosis is made up. However, most clinicians do not recommend the shunt operation to their patients with presumed idiopathic normal pressure hydrocephalus unless any patients with idiopathic normal pressure hydrocephalus show a considerable improvement through the cerebrospinal fluid tap test.
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