Publications by authors named "Kyuho Bang"
Article Synopsis
- - The study focused on improving the bioavailability of olaparib (OLA), a drug for ovarian and breast cancer, by creating stable solid dispersions using various polymers, particularly hypromellose (HPMC).
- - Researchers utilized techniques like SEM, DSC, PXRD, and FT-IR to analyze the properties of the OLA-loaded solid dispersions and found that HPMC maintained the drug's amorphous state and prevented recrystallization.
- - In vivo testing showed that the HPMC-based solid dispersion significantly increased OLA's bioavailability, with a 4.19-fold increase in the area under the curve (AUC) and over a 10.68-fold increase in the maximum concentration (C)
NIR spectroscopy has been extensively employed for the in-line monitoring of pharmaceutical processes as one of the key PAT implementation tools. Nevertheless, pharmaceutical processes such as fluid-bed coating have not fully made the most of the NIR in-line monitoring primarily due to a difficulty in handling random in-line spectra. In this study, novel approaches to develop a reasonable dynamic calibration model were proposed; averaging and clustering.
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