Publications by authors named "Kyubin Seo"
Adv Sci (Weinh)
July 2023
Article Synopsis
- - The study explores how symmetry breaking in human pluripotent stem cells (hPSCs) can mimic the processes of axis formation and cell patterning during development.
- - Researchers created polarized spinal cord organoids (pSCOs) that exhibit organized dorsoventral (DV) structures and can differentiate into specific cell types through the application of specific signals.
- - The control of dorsal/ventral domain proportions in pSCOs is achieved by adjusting the sizes of the initial cell micropatterns, resulting in distinct neural activities in mature organoids, which sheds light on the principles of neural development.
Stem Cell Reports
January 2022
Article Synopsis
- Human pluripotent stem cell (hPSC) colonies exhibit structural and functional differences based on their position, particularly in apical features that influence cell behavior.
- Edge cells in these colonies show different gene expression patterns related to cell movement and polarization compared to center cells.
- The study highlights that actin dynamics are crucial for maintaining the unique properties of these position-dependent cells, and a dye-labeling technique can help sort specific cell populations in differentiated colonies.
