ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress.

The proximal domains of mitochondria and the endoplasmic reticulum (ER) are linked by tethering factors on each membrane, allowing the efficient transport of substances, including lipids and calcium, between them. However, little is known about the regulation and function of mitochondria-ER contacts (MERCs) dynamics under mitochondrial damage. In this study, we apply NanoBiT technology to develop the MERBiT system, which enables the measurement of reversible MERCs formation in living cells.

Transcriptional Regulation of the Outer Membrane Protein A in .

is known for its virulence in severely ill, hospitalized patients and for exhibiting multidrug resistance. infection treatment poses a serious problem in clinical environments. The outer membrane protein A () of the Acinetobacter genus is involved in bacterial virulence.