Publications by authors named "Kyu Na Lee"
Article Synopsis
- Diabetes mellitus (DM) and alcohol consumption are both risk factors for tuberculosis (TB), prompting a study on their relationship specifically in individuals with type 2 DM (T2DM).
- The study followed over 2.4 million T2DM patients from 2009 to 2018, identifying the effects of alcohol consumption on TB development, with findings categorized into non-drinkers, mild-to-moderate drinkers, and heavy drinkers.
- Results indicated that mild-to-moderate drinkers had a lowered risk of TB, while heavy drinkers showed an increased risk, especially those consuming 20 g/day or more; additionally, current smokers also faced heightened risks, making the relationship complex.
Article Synopsis
- * Results showed that individuals with MetS had a higher risk of COPD, with specific components such as abdominal obesity, hypertension, and low HDL cholesterol being significantly associated with increased risk.
- * The findings indicate that as the number of MetS components increases, so does the risk of developing COPD, highlighting the importance of monitoring young individuals with MetS for potential respiratory issues.
Article Synopsis
- A study explored the link between metabolic dysfunction-associated steatotic liver disease (MASLD) and heart failure/cardiovascular mortality in patients with type 2 diabetes mellitus (T2DM).
- Over 2.7 million T2DM adults were monitored from 2009 to 2018, revealing that those with various types of steatotic liver disease had a significantly higher risk of heart failure and cardiovascular death compared to those without.
- The findings indicate that SLD is an independent risk factor for heart failure and cardiovascular mortality in T2DM patients, with alcohol consumption showing a J-shaped relationship with these risks.
Although smoking is an established risk factor for Mycobacterial infection, the association between smoking and nontuberculous mycobacterial pulmonary disease (NTM-PD) remains unclear. We evaluated the association between smoking and NTM-PD and tuberculosis (TB) using a population-based South Korean nationwide cohort. Using the Korean National Health Insurance Database, we screened individuals over 20 years of age who underwent the national health screening program in 2009.
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- - The study analyzed risk factors for abdominal aortic aneurysm (AAA) development in adults over 50 with diabetes, highlighting that despite diabetes being linked to a lower AAA risk, some patients still develop it.
- - It followed over 1.9 million participants from 2009 to 2019 and found factors like age, male gender, smoking, and certain health issues (e.g., hypertension) increased AAA risk, while longer diabetes duration and specific oral medications decreased risk.
- - Notably, the research indicated that heavy alcohol consumption and obesity were linked to lower AAA risk, whereas insulin use marginally increased risk, showcasing a complex relationship between diabetes management and AAA development.
Article Synopsis
- The study explored the link between nonalcoholic fatty liver disease (NAFLD) and the risk of developing atrial fibrillation (AF), considering factors such as age and liver fibrosis.
- Researchers analyzed data from over 3 million participants, categorizing them based on their NAFLD status and identifying new cases of AF over a median follow-up of 9.3 years.
- The findings indicated that the risk of new-onset AF significantly increased with both the severity of NAFLD and the presence of advanced fibrosis, particularly among younger individuals aged 20-29.
Background: The relationship between circulating lipid levels and the risk for heart failure (HF) is controversial. We aimed to examine this association, and whether it is modified by the duration of diabetes or treatment regimens in people with type 2 diabetes mellitus.
Methods: Individuals (n=2,439,978) who underwent health examinations in 2015 to 2016 were identified from the Korean National Health Information Database.
Background: Low socioeconomic status is a risk factor for chronic obstructive pulmonary disease (COPD); however, the association between low household income and COPD in young populations remains unclear.
Methods: We screened individuals aged 20-39 years who underwent the national health examination between 2009 and 2012 using the Korean National Health Information Database, which was searched until December 2019. We identified 5 965 366 eligible individuals, and 13 296 had newly developed COPD based on health insurance claims.
Purpose: This study was performed to assess the lifestyle-related behaviors of patients with gastric cancer (GC) and to investigate the associations between the time since GC diagnosis and these behaviors.
Materials And Methods: This study included 29,478 adults (including 338 patients with GC) aged ≥ 40 years who participated in the Korea National Health and Nutrition Examination Survey 2014-2021. Multiple logistic regression analysis explored the associations between the time since GC diagnosis (patients diagnosed with GC less than 5 years ago [<5 years group] and those diagnosed with GC 5 or more than years ago [≥5 years group]) and lifestyle factors.
Article Synopsis
- This study analyzed a large dataset from the Korean National Health Insurance Service to explore the relationship between diabetes mellitus (DM), impaired fasting glucose (IFG), and abdominal aortic aneurysm (AAA) over a ten-year period.
- Participants aged 50 and older showed a lower incidence of AAA among those with IFG or DM compared to those with normal blood sugar, with a stronger risk reduction observed for those with longer diabetes duration.
- The findings suggest that both IFG and untreated DM are independently associated with a reduced risk of developing AAA, contradicting some previous assumptions about the relationship between these conditions.
An association between psoriasis and cancer risk has been suggested in prior studies, but few have focused on head and neck cancers. Using the Korean National Health Insurance Service database, the relevance between psoriasis and head and neck cancer risks was investigated in a cross-sectional study of 3,869,264 individuals over 20 years of age, who received general health examination in 2009 and were followed until 2020. Head and neck cancer incidence rates were compared between individuals with and without psoriasis, and contributing factors were analysed.
View Article and Find Full Text PDFPhysical Activity and the incidence of sepsis: A 10-year observational study among 4 million adults.
J Microbiol Immunol Infect
June 2024
Article Synopsis
Article Synopsis
- A study was conducted to explore the relationship between serum gamma-glutamyl transferase (GGT) levels and mortality rates in patients with type 2 diabetes, utilizing a large Korean health-screening database.
- Out of nearly 10 million participants observed over an average of 8.1 years, higher GGT levels were linked to increased all-cause mortality and specific causes of death, such as cardiovascular diseases, cancer, and liver disease.
- The findings suggest that measuring serum GGT levels could be beneficial for evaluating mortality risk in individuals with type 2 diabetes.
Article Synopsis
- Sepsis is a significant global health issue with high mortality rates and no specific treatment, yet the relationship between smoking and sepsis has not been thoroughly studied.
- This research analyzed data from over 4 million adults in South Korea who were monitored for 10 years, assessing their smoking status and incidence of sepsis.
- The findings indicate that both active and former smokers, especially those with a history of smoking 20 or more pack-years, have a significantly increased risk of developing sepsis, suggesting that quitting smoking may help reduce this risk.
Diabetes Duration, Cholesterol Levels, and Risk of Cardiovascular Diseases in Individuals With Type 2 Diabetes.
J Clin Endocrinol Metab
November 2024
Article Synopsis
- The study aimed to explore how the duration of diabetes impacts the risk of cardiovascular diseases (CVD) and how lipid levels relate to this risk over time.
- Researchers analyzed data from over 2.3 million individuals with type 2 diabetes, focusing on their lipid levels and diabetes duration from 2015 to 2020.
- The findings indicated that the LDL cholesterol (LDL-C) levels at which CVD risk increases differ depending on how long someone has had diabetes, suggesting that treatment targets for LDL-C should be adjusted based on diabetes duration.
Article Synopsis
- Heart failure (HF) is a common issue for individuals with type 2 diabetes, and the study investigates how changes in smoking habits can affect the risk of developing HF in this group.
- A retrospective cohort study tracked over 365,000 smokers with type 2 diabetes, revealing that quitting smoking reduced the risk of HF, while increasing smoking levels raised the risk, especially for heavy smokers.
- The findings underscore that cessation of smoking is beneficial for reducing HF risk, whereas cutting down smoking doesn't necessarily lead to improved outcomes.
Backgruound: We aimed to identify the risk of incident depression according to cumulative exposure to a low-household income status in individuals with type 2 diabetes mellitus (T2DM).
Methods: For this retrospective longitudinal population-based cohort study, we used Korean National Health Insurance Service data from 2002 to 2018. Risk of depression was assessed according to cumulative exposure to low-household income status (defined as Medical Aid registration) during the previous 5 years among adults (aged ≥20 years) with T2DM and without baseline depression who underwent health examinations from 2009 to 2012 (n=2,027,317).
The relationship between prediabetes and dementia remains controversial. We aimed to examine the association between cumulative exposure to impaired fasting glucose (IFG) and the risk of dementia in the general population. 1,463,066 middle-aged and elderly subjects who had had health examinations for four consecutive years were identified from a Korean nationwide population-based cohort database.
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- The study aimed to investigate the potential link between metabolic syndrome (MetS) and the risk of developing abdominal aortic aneurysm (AAA) in a large group of individuals aged 50 and over.
- Using data from over 4 million participants, researchers found that those with MetS had a significantly higher risk of developing AAA compared to those without it, especially if they had multiple components of MetS.
- Among MetS components, elevated waist circumference, blood pressure, triglycerides, and low HDL-C were associated with increased AAA risk; notably, elevated glucose was linked to a reduced risk, indicating a complex relationship between MetS and AAA.
Smoking patients with diabetes mellitus (DM) are at greater risk of developing pneumonia. How smoking behavior changes affect the risk of pneumonia hospitalization, however, remains unclear. Therefore, we investigated the association between smoking behavior change and the risk of pneumonia hospitalization in patients with DM.
View Article and Find Full Text PDFBackground: Cigarette smoking is an important risk factor for developing chronic obstructive pulmonary disease (COPD). However, the effect of smoking on the development of COPD in young individuals remains unclear. We aimed to evaluate the effect of smoking on COPD development in young individuals.
View Article and Find Full Text PDFBackground: We aimed to examine the association between smoking behavior change and risk of cardiovascular disease (CVD) incidence and mortality in patients with type 2 diabetes mellitus (T2DM).
Methods: This study used nationwide data from the Korean National Health Insurance System and included 349,137 T2DM patients who smoked. Smoking behavior changes were defined with five groups: quitters, reducers I (≥ 50% reduction), reducers II (20-50% reduction), sustainers (± 20%), and increasers (≥ 20% increase) from the number of cigarettes/day at the baseline.
Purpose: The purpose of this study was to identify diabetes-related risk factors for exudative age-related macular degeneration (AMD).
Methods: This was a nationwide population-based cohort study using authorized clinical data provided by the Korean National Health Insurance Service. A total of 1,768,018 participants with diabetes over 50 years of age participated in the Korean National Health Screening Program between 2009 and 2012.
Backgruound: We explored the risk of death from pneumonia according to cumulative duration in low household income state (LHIS) among adults with type 2 diabetes mellitus (T2DM).
Methods: Using Korean National Health Insurance Service data (2002 to 2018), the hazards of mortality from pneumonia were analyzed according to duration in LHIS (being registered to Medical Aid) during the 5 years before baseline (0, 1-4, and 5 years) among adults with T2DM who underwent health examinations between 2009 and 2012 (n=2,503,581). Hazards of outcomes were also compared in six groups categorized by insulin use and duration in LHIS.
Introduction: Although an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease or overall mortality has been reported, it is unclear whether there is an association between MAFLD and cancer incidence or mortality. We aimed to investigate the differential risk of all- and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver disease.
Methods: Using the Korean National Health Insurance Service database, we stratified the participants into three groups: (1) single-etiology MAFLD (S-MAFLD) or MAFLD of pure metabolic origin; (2) mixed-etiology MAFLD (M-MAFLD) or MAFLD with additional etiological factor(s) (i.