Publications by authors named "Kyu Lee"

Interstitial quasi-atomic electrons (IQEs) in the quantized energy levels of positively charged cavities possess a substantial own magnetic moment and control the magnetism of crystalline electrides depending on the interaction with surrounding cations. However, weak spin-orbit coupling and gentle exchange interaction restricted by the IQEs preclude a large magnetic anisotropic, remaining a challenge for a hard magnetism. It is reported that 2D [ReC]·2e electrides (Re = Er, Ho, Dy, and Tb) show the permanent magnetism in a ferrimagnetic ground state, mimicking the ferrites composed of magnetic sublattices with different spin polarizations.

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Body mass index (BMI) is associated with chronic obstructive pulmonary disease (COPD) risk. We investigated the association between BMI and the risk of COPD among young individuals. Using the Korean National Health Information Database, we screened individuals aged 20-39 years who participated in the national health examination between 2009 and 2012.

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Diffuse midline gliomas with H3 K27-alteration (DMGH3) are lethal and inoperable brain tumors. Although DMGH3s mainly occur in pediatric patients, they have also occurred in adult patients. This study aimed to analyze the clinicopathological significance of targetable genetic alterations in non-pediatric DMGH3.

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  • The study compared two AI tools, M4CXR and ChatGPT-4o, for interpreting chest X-rays, using 826 images from Inha University Hospital.
  • M4CXR outperformed ChatGPT in diagnostic accuracy (60-62% vs. 42-45%) and anatomical localization (76-77.5% vs. 36-36.5%), with both showing high agreement between radiologists.
  • These findings suggest that while M4CXR excels in specialized analysis, integrating both AI tools could improve diagnostic workflows and patient care by combining AI strengths with human expertise.
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A vision transformer (ViT)-based deep neural network was applied to classify the flavonoid glycoside isomers by analyzing electrospray ionization tandem mass spectrometry (ESI-MS/MS) spectra. Our model successfully classified the flavonoid isomers with various substitution patterns (3-O, 6-C, 7-O, 8-C, 4'-O) and multiple glycosides, achieving over 80% accuracy during training. In addition, the experimental spectra from flavonoid glycoside standards were acquired with different adducts, and our model showed robust performance regardless of the experimental conditions.

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The rice small protein OsS1Fa1, a homolog of spinach S1Fa, plays a significant role in drought tolerance, attributed to its transmembrane domain. In this study, we aim to further elucidate the potential roles of OsS1Fa1 in cold and biotic stresses as an inner nuclear membrane protein. Fluorescence analysis confirmed the localization of OsS1Fa1 to the inner nuclear membrane.

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The latest advancement in high-intensity focused ultrasound (HIFU) treatment technology integrates magnetic resonance imaging (MRI) guidance for precise treatment of prostate disease. As conventional electromagnetic motors are not applicable for utilization within MRI scanners, we have developed a prototype robotic system driven by pneumatic stepper motors to control the movement of the HIFU transducer within an intrarectal probe during MRI-guided HIFU treatment procedures. These pneumatic stepper motors were constructed entirely from MRI-compatible plastic materials.

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  • Diabetes mellitus (DM) and alcohol consumption are both risk factors for tuberculosis (TB), prompting a study on their relationship specifically in individuals with type 2 DM (T2DM).
  • The study followed over 2.4 million T2DM patients from 2009 to 2018, identifying the effects of alcohol consumption on TB development, with findings categorized into non-drinkers, mild-to-moderate drinkers, and heavy drinkers.
  • Results indicated that mild-to-moderate drinkers had a lowered risk of TB, while heavy drinkers showed an increased risk, especially those consuming 20 g/day or more; additionally, current smokers also faced heightened risks, making the relationship complex.
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Introduction: Polygoni Multiflori Radix (PMR) is commonly used in traditional medicine as both raw and processed forms. Raw PMR was prepared into processed PMR via processing procedure; however, there is a lack of standardized protocols ensuring the completeness of processing.

Objective: This aims to develop a strategy based on a metabolomics approach for the comprehensive chemical profiling and comparison of raw and processed PMR and establish a basis for PMR processing standardization.

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  • * Results showed that individuals with MetS had a higher risk of COPD, with specific components such as abdominal obesity, hypertension, and low HDL cholesterol being significantly associated with increased risk.
  • * The findings indicate that as the number of MetS components increases, so does the risk of developing COPD, highlighting the importance of monitoring young individuals with MetS for potential respiratory issues.
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To investigate the association between obesity and blood lead level (BLL) in the general population after controlled for menopause, blood pressure, calcium, and smoking; we assessed the relationship between BMI, WC (Waist Circumference), and blood lead levels in the non-smoking middle-aged subjects without hypertension among 2018 KNHANES. All data were recategorized into S1 (BMI<25 kg/m & WC<90 cm), S2 (intermediate), and S3 (BMI>25 kg/m & WC>90 cm). We made the log transformation of blood lead levels to bring them closer to a normal distribution.

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Background: Patients with borderline resectable (BR) or locally advanced pancreatic cancer (LAPC) require complex management strategies. This study evaluated the prognostic significance of the perichemotherapy skeletal muscle index (SMI) and carbohydrate antigen 19-9 (CA 19-9) in patients with BRPC or LAPC treated with FOLFIRINOX.

Methods: We retrospectively evaluated 227 patients with BR or LAPC who received at least four cycles of chemotherapy between 2015 and 2020.

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In this study, we demonstrate the emergence of NO gas sensing capabilities in the typically non-active NiWO, a strongly correlated electron system (SCES), by introducing substitutional Fe at the Ni site. NiWO typically exhibits strong Coulombic repulsion between Ni atoms, resulting in a large band gap of over 3.0 eV and insulating behavior.

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  • MEN1 is an autosomal dominant condition leading to tumors in various endocrine organs, primarily identified through genetic variants in the MEN1 gene, and this study focused on a Korean cohort to understand these features better.
  • Analyzed data from 117 MEN1 patients revealed that the most frequent symptom was primary hyperparathyroidism, with a high occurrence of gastroenteropancreatic and pituitary neuroendocrine tumors recorded.
  • Genetic testing identified 61 unique MEN1 variants, including 18 new ones, indicating a stronger link between truncating variants and a higher rate of pituitary tumors, emphasizing the significance of genetic testing in managing MEN1.
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  • Ultrasound equipment is crucial for diagnosing internal conditions, but image quality is often subjective and varies based on the evaluator's experience, leading to potential misdiagnosis.
  • This study introduces a two-stage deep learning framework that objectively assesses ultrasound image quality based on three important factors: 'Dead zone', 'Axial/lateral resolution', and 'Gray scale and dynamic range'.
  • The deep learning model shows excellent performance, with high AUC scores, demonstrating its effectiveness in providing consistent quality control and an overall equipment quality score for ultrasound machines.
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The demand for gas-sensing operations with lower electrical power and guaranteed sensitivity has increased over the decades due to worsening indoor air pollution. In this report, we develop room-temperature operational NH gas-sensing materials, which are activated through electron doping and crystal structure distortion effect in FeNiWO. The base material, synthesized through solid-state synthesis, involves Fe cations substitutionally located at the Ni sites of the NiWO crystal structure and shows no gas-sensing response at room temperature.

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Paper crafts, such as origami and kirigami, have become an interdisciplinary research theme transportable from art to science, and further to engineering. Kirigami-inspired architectural design strategies allow the establishment of three-dimensional (3D) mechanical linkages with unprecedented mechanical properties. Herein, we report a crystalline zeolitic imidazolate framework (ZIF), displaying folding mechanics based on a kirigami tessellation, originated from the double-corrugation surface (DCS) pattern.

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Objective: To investigate longitudinal changes in plantar pressure examinations and plain radiographs and to assess the correlations between these two modalities in pediatric patients with flexible flatfoot (FFF).

Methods: Pediatric patients diagnosed with FFF were analyzed in this retrospective cohort study. Medical records were reviewed to collect data on plain radiographs and plantar pressure examinations.

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Backgruound: Medullary thyroid carcinoma (MTC) has a poorer prognosis than differentiated thyroid cancers; however, comprehensive data on the long-term outcomes of MTC remain scarce. This study investigated the extended clinical outcomes of MTC and aimed to identify prognostic factors.

Methods: Patients diagnosed with MTC between 1980 and 2020 were retrospectively reviewed.

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Micrometer-sized single crystal cathodes have garnered significant interest as promising cathode materials for lithium-ion batteries due to their ability to reduce surface area exposure to electrolytes and suppress side reactions, thereby enhancing electrochemical performance. One of the challenging issues with single crystal cathode materials is synthesizing monodisperse and discrete single crystals rather than agglomerated quasi-single crystals. However, conventional solid-state synthesis of most single crystals results in severe agglomeration and cation mixing, as it requires high temperatures to promote particle growth to several micrometers.

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Clusters of similar or dissimilar objects are encountered in many fields. Frequently used approaches treat each cluster's central object as latent. Yet, often objects of one or more types cluster around objects of another type.

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Controlling the microenvironment surrounding the pluripotent stem cells (PSCs) is a pivotal strategy for regulating cellular differentiation. Surface nanotopography is one of the key factors influencing the lineage-specific differentiation of PSCs. However, much of the underlying mechanism remains unknown.

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Room temperature gas sensing is crucial for practical devices used in indoor environments. Among various materials, metal oxides are commonly used for gas sensing, but their strong insulating properties limit their effectiveness at room temperature. To address this issue, many studies have explored diverse methods such as nanoparticle decoration or conductive support, etc.

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  • Tolvaptan, a medication approved in Korea for treating autosomal dominant polycystic kidney disease (ADPKD), was evaluated in a phase 4 clinical trial involving 117 patients with chronic kidney disease stages 1 to 3 over 24 months.* -
  • The study recorded a high rate of treatment-emergent adverse events (TEAEs), with 90.6% of patients experiencing them, including 14.5% reporting hepatic adverse events, which improved after stopping the medication.* -
  • Despite a higher incidence of liver-related issues compared to previous studies, the results suggest that tolvaptan can be used safely and effectively with careful dosage adjustments and regular monitoring.*
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Electron-transporting transparent conducting oxides (TCOs) are a commercial reality, however, hole-transporting counterparts are far more challenging because of limited material design. Here, we propose a strategy for enhancing the hole conductivity without deteriorating the band gap () and workfunction () by Cu incorporation in a strongly correlated NiWO insulator. The optimal Cu-doped NiWO (CuNiWO) exhibits a resistivity reduction of ∼10 times NiWO as well as band-like charge transport with the hole mobility approaching 7 cm V s at 200 K, a deep of 5.

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