Clinical experience of switching anti-VEGF therapy from ranibizumab to aflibercept in age-related choroidal neovascularization.

Purpose: To report the response of participants switching from ranibizumab to aflibercept treatment for neovascular age-related macular degeneration (nAMD) requiring further anti-vascular endothelial growth factor treatment.

Methods: In this retrospective case review of 68 participants treated in a single hospital, all participants, prior to switching, received ranibizumab injections only. Best-corrected visual acuity (BCVA), clinical examination, and optical coherence tomography (OCT) were performed at each visit.

Biomechanical and optical behavior of human corneas before and after photorefractive keratectomy.

Purpose: To evaluate numerically the biomechanical and optical behavior of human corneas and quantitatively estimate the changes in refractive power and stress caused by photorefractive keratectomy (PRK).

Setting: Athineum Refractive Center, Athens, Greece, and Politecnico di Milano, Milan, Italy.

Design: Retrospective comparative interventional cohort study.

Optical coherence tomography, Scheimpflug imaging, and slit-lamp biomicroscopy in the early detection of graft detachment after Descemet membrane endothelial keratoplasty.

Purpose: To evaluate the efficacy of anterior segment optical coherence tomography (OCT), Scheimpflug imaging, and slit-lamp biomicroscopy in the early detection of a (partial) graft detachment after Descemet membrane endothelial keratoplasty (DMEK).

Methods: Anterior segment OCT, Scheimpflug imaging, and slit-lamp biomicroscopy were performed in 120 eyes of 110 patients after DMEK.

Results: Seventy-eight eyes showed a normal corneal clearance, and the attached Descemet grafts could not be identified with any of the imaging techniques.

Refractive change and stability after Descemet membrane endothelial keratoplasty. Effect of corneal dehydration-induced hyperopic shift on intraocular lens power calculation.

Purpose: To determine the refractive change and stability of the transplanted cornea after Descemet membrane endothelial keratoplasty (DMEK) through a 3.0 mm clear corneal incision.

Setting: Tertiary referral center.

Learning Curve in Descemet's Membrane Endothelial Keratoplasty: First Series of 135 Consecutive Cases.

Purpose: To evaluate the learning curve in Descemet's membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders.

Design: Retrospective, nonrandomized, clinical study at a tertiary referral center.

Participants: We included 135 eyes of 118 patients with Fuchs' endothelial dystrophy.

Efficacy of descemet membrane endothelial keratoplasty: clinical outcome of 200 consecutive cases after a learning curve of 25 cases.

Objective: To evaluate Descemet membrane endothelial keratoplasty for management of corneal endothelial disorders.

Methods: Descemet membrane endothelial keratoplasty was performed in 200 patients with Fuchs endothelial dystrophy or bullous keratopathy. Best-corrected visual acuity, subjective and objective refractive outcome and stability, and endothelial cell density were evaluated at 1, 3, and 6 months postoperatively, and intraoperative and postoperative complications were documented.

Standardized "no-touch" technique for descemet membrane endothelial keratoplasty.

We describe a standardized technique for "no-touch" isolated Descemet membrane transplant, ie, Descemet membrane endothelial keratoplasty (DMEK). All essential steps, including patient preparation and descemetorhexis as well as DMEK graft implantation, orientation, unrolling, centering, appositioning, and fixation, are described in detail. In the management of Fuchs endothelial dystrophy, the technique may provide a best-corrected visual acuity of 20/25 or better (≥ 0.