Publications by authors named "Kyriaki Z Thanos"
Article Synopsis
- Alcohol use disorder (AUD) accounts for about 13% of US deaths and leads to family destruction and economic losses from reduced work performance and healthcare costs.
- Research indicates specific brain receptors (NMDAR) influenced by AUD, which affect emotional and behavioral responses.
- The review suggests that aerobic exercise may positively impact these brain receptors and serve as a helpful additional treatment for AUD, highlighting the need for more studies in this area.
Epidermal/brain fatty acid-binding protein 5 (FABP5) plays an integral role in the intracellular trafficking of bioactive lipids/endocannabinoids and the subsequent initiation of cellular cascades affecting cannabinoid and dopamine (DA) systems. Social isolation (SI) and environmental enrichment (EE) during adolescence have been shown to impact DA signaling, and, specifically, DA transporter (DAT) and receptor levels of DA type 1 (D1) and 2 (D2); however, the relationship between FABP5, environment and DA signaling remains unclear. The present study quantified DAT and DA receptor levels in male/female FABP5-/- and FABP5+/+ mice raised in either SI or EE.
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