Publications by authors named "Kyra E Fryling"
Article Synopsis
- Neisseria gonorrhoeae poses a significant public health risk due to rising cases and antimicrobial resistance, with whole-genome sequencing (WGS) evaluated for predicting susceptibility to various antimicrobials.
- 481 isolates from five countries were analyzed, revealing that susceptibility to ciprofloxacin is linked to a specific genetic marker (gyrA codon 91), while predicting susceptibility to other drugs requires a multilocus approach.
- All isolates tested were susceptible to zolifodacin, and while a single marker can guide ciprofloxacin treatment, a combination of markers is necessary for other medications.
Background: Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials of new antibiotics reported for oropharyngeal infections compared with other sites of infection.
View Article and Find Full Text PDF