Reconstructed three-dimensional structure of gas-foamed polycaprolactone/cellulose nanofibrous scaffold for biomedical applications.

One of the unavoidable issues with the bio-scaffolding process is the collapse of the visually appealing external three-dimensional (3D) sponge-like structure and the internal porous and multilayered morphology of a gas-foamed nanofibrous scaffold. Herein, a gas-foamed polycaprolactone/cellulose (g-PCL/CL) nanofibers scaffold is first prepared by electrospinning PCL/cellulose acetate, followed by deacetylation and then Sodium borohydride-assisted gas-foaming technique. The deformed 3D architecture of g-PCL/CL nanofiber is finally reconstructed by mixing it with chitosan (CS) solution and molding.

Quantification of steal flow on Doppler ultrasound in patients with arteriovenous graft for hemodialysis.

Purpose: Arteriovenous fistula (AVF) is the preferred treatment for long-term hemodialysis patients to allow reliable vascular access. Arteriovenous graft (AVG) is monitored using Doppler sonography to check a vessel's condition and predict complications such as steal syndrome. In this study, we developed an analysis algorithm and method to quantify steal syndrome using Doppler sonography.

Controlled generation of nanopatterned electrical DNA interface.

Techniques that manipulate DNA, a biomolecule with electrical properties, are in demand in various medical fields. This study fabricated a nanochannel with a conductive/semi-conductive interface using focused ion beams (FIBs) and introduced a nanochip technology to freely align, attach, and detach lambda DNAs in the interface via electrophoresis. Two-step fabrication process of nanochannels was quantitatively characterized according to the different conditions of the FIB dose (1~30 nC/μm) and current (1~500 pA).