Publications by authors named "Kyoungeun A Kim"
Article Synopsis
- The study investigates how TRP channels (specifically TRPA1, TRPV1, and TRPC) in guinea pig urinary bladders affect bladder function by releasing neurotransmitters.
- Agonists like AITC, CAPS, and OA-NO were tested, revealing that AITC significantly increased bladder contractions, an effect that could be influenced by certain antagonists and inhibitors.
- Findings suggest that there are at least two types of afferent nerves in the guinea pig bladder: Type A (TRPA1 receptors) which stimulate contractions, and Type B (TRPV1, TRPA1, TRPC receptors) which can inhibit them through CGRP release.
The effects of intravesical administration of a muscarinic receptor agonist (oxotremorine-M, OXO-M) and antagonist (atropine methyl nitrate, AMN) and of a nicotinic receptor agonist (nicotine) and antagonist (hexamethonium, C) on reflex bladder activity were investigated in conscious female chronic spinal cord injured (SCI) cats using cystometry. OXO-M (50μM) decreased bladder capacity (BC) for triggering micturition contractions, increased maximal micturition pressure (MMP), increased frequency and area under the curve of pre-micturition contractions (PMC-AUC). Nicotine (250μM) decreased BC, increased MMP, but did not alter PMC-AUC.
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