Publications by authors named "Kyoung Ryun Park"
Purpose: Fixed-dose combination (FDC) of gemigliptin and rosuvastatin may improve medication compliance of patients with comorbid type 2 diabetes and dyslipidemia. Pharmacokinetics (PK), pharmacodynamics (PD), and safety of gemigliptin/rosuvastatin 50/20 mg FDC was compared with a loose combination of individual tablets in healthy subjects.
Patients And Methods: A randomized, open-label, single-dose, two-period, two-sequence, two-treatment crossover study was conducted.
Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram.
Basic Clin Pharmacol Toxicol
February 2018
Vancomycin is a glycopeptide antibiotic used to treat Gram-positive infections including methicillin-resistant Staphylococcus aureus (MRSA). The objectives of this study were to evaluate the appropriateness of the initial dosing regimen of vancomycin, identify factors to be considered in regimen selection and develop a new dosing nomogram. Therapeutic drug monitoring (TDM) data of vancomycin obtained from Seoul National University Hospital from 2011 to 2013 were included in this analysis.
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- - The study compared the pharmacokinetics (PK), immunogenicity, and tolerability of LBAL (a biosimilar to Humira) with the original drug in healthy subjects, using a randomized, double-blind design with 116 participants who received one of the two medications.
- - Results showed comparable PK characteristics for both drugs, with geometric mean ratios (GMRs) falling within bioequivalence boundaries, indicating they are effectively similar in how they perform in the body.
- - Both LBAL and Humira displayed similar immunogenicity rates and tolerability profiles, meaning they had comparable side effects and immune responses, confirming LBAL as a well-tolerated alternative to Humira.
A Gram-negative, UV tolerant bacterial strain, DG7A(T), was isolated from soil samples collected in Seoul city, South Korea. The cells were grown on R2A agar at 25 °C and were pink to red in color. The DNA G+C content of the novel strain DG7A was 63.
View Article and Find Full Text PDFA Gram-negative, short-rod-shaped bacterial strain with gliding motility, designated as DG5A(T), was isolated from a rice field soil in South Korea. Phylogenic analysis using 16S rRNA gene sequence of the new isolate showed that strain DG5A(T) belong to the genus Spirosoma in the family Spirosomaceae, and the highest sequence similarities were 95.5 % with Spirosoma linguale DSM 74(T), 93.
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