Publications by authors named "Kyongtae Tae Bae"
Background: Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
Methods: A phase II, double-blinded randomized placebo-controlled trial of 26 months duration.