Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow.

Memory T (T) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how T cells receive these signals, we infected mice with lymphocytic choriomeningitis virus (LCMV) and examined the expression sites of neural cadherin (N-cadherin) by immunofluorescence microscopy.

Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors.

Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-related diseases, no small molecule that inhibits IL-33 has been reported. Based on the structure-activity relationship and in vitro 2D NMR studies employing N-labeled IL-33, we identified that the oxazolo[4,5-c]-quinolinone analog 7 c binds to the interface region of IL-33 and IL-33 receptor (ST2), an orphan receptor of the IL-1 receptor family.

Energy Harvested and Cooperative Enabled Efficient Routing Protocol (EHCRP) for IoT-WBAN.

The health industry is one of the most auspicious domains for the application of Internet of Things (IoT) based technologies. Lots of studies have been carried out in the health industry field to minimize the use of resources and increase the efficiency. The use of IoT combined with other technologies has brought quality advancement in the health sector at minimum expense.

Adaptive Real-Time Routing Protocol for (,)-Firm in Industrial Wireless Multimedia Sensor Networks.

Many applications are able to obtain enriched information by employing a wireless multimedia sensor network (WMSN) in industrial environments, which consists of nodes that are capable of processing multimedia data. However, as many aspects of WMSNs still need to be refined, this remains a potential research area. An efficient application needs the ability to capture and store the latest information about an object or event, which requires real-time multimedia data to be delivered to the sink timely.

Opportunistic Multipath Routing in Long-Hop Wireless Sensor Networks.

To improve the packet delivery ratio in wireless sensor networks, many approaches such as multipath, opportunistic, and learning-based routing protocols have been proposed. However, the performance of the existing protocols are degraded under long-hop wireless sensor networks because the additional overhead is proportional to the number of hops. To deal with the overhead, we propose an opportunistic multipath routing that forecasts the required number of paths, as well as bifurcation based on opportunistic routing according to the reliability requirement.

Wireless Sensor Networks for Big Data Systems.

Before discovering meaningful knowledge from big data systems, it is first necessary to build a data-gathering infrastructure. Among many feasible data sources, wireless sensor networks (WSNs) are rich big data sources: a large amount of data is generated by various sensor nodes in large-scale networks. However, unlike typical wireless networks, WSNs have serious deficiencies in terms of data reliability and communication owing to the limited capabilities of the nodes.

Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients.

Sphingosine-1-phosphate (S1P) plays an important role in trafficking leukocytes and developing immune disorders including autoimmunity. In the synovium of rheumatoid arthritis (RA) patients, increased expression of S1P was reported, and the interaction between S1P and S1P receptor 1 (S1P1) has been suggested to regulate the expression of inflammatory genes and the proliferation of synovial cells. In this study, we investigated the level of S1P1 mRNA expression in the blood leukocytes of RA patients.

Energy-Efficient Region Shift Scheme to Support Mobile Sink Group in Wireless Sensor Networks.

Mobile sink groups play crucial roles to perform their own missions in many wireless sensor network (WSN) applications. In order to support mobility of such sink groups, it is important to design a mechanism for effective discovery of the group in motion. However, earlier studies obtain group region information by periodic query.

A Tree Based Broadcast Scheme for (m, k)-firm Real-Time Stream in Wireless Sensor Networks.

Recently, various unicast routing protocols have been proposed to deliver measured data from the sensor node to the sink node within the predetermined deadline in wireless sensor networks. In parallel with their approaches, some applications demand the specific service, which is based on broadcast to all nodes within the deadline, the feasible real-time traffic model and improvements in energy efficiency. However, current protocols based on either flooding or one-to-one unicast cannot meet the above requirements entirely.

A Survey on Mobility Support in Wireless Body Area Networks.

Wireless Body Area Networks (WBANs) have attracted research interests from the community, as more promising healthcare applications have a tendency to employ them as underlying network technology. While taking design issues, such as small size hardware as well as low power computing, into account, a lot of research has been proposed to accomplish the given tasks in WBAN. However, since most of the existing works are basically developed by assuming all nodes in the static state, these schemes therefore cannot be applied in real scenarios where network topology between sensor nodes changes frequently and unexpectedly according to human moving behavior.

Estrogenic endocrine-disrupting chemicals modulate the production of inflammatory mediators and cell viability of lipopolysaccharide-stimulated macrophages.

Estrogenic endocrine-disrupting chemicals (EDCs) are exogenous substances that act as competitive inhibitors of estrogen in the endocrine system. By disrupting the endocrine system, EDCs can cause severe disabilities and diseases, including cancers and altered sexual development. Although the influence of these molecules in the endocrine system is evident, the effects of EDCs on the immune system as well as their cytotoxicity have been poorly examined.

Diverse influences of androgen-disrupting chemicals on immune responses mounted by macrophages.

Androgen-disrupting chemicals (ADCs) can alter male sexual development. Although the effects of ADCs on hormone disruption have been studied, their influence on the immune response is not fully understood. To investigate the effects of ADCs on innate immunity, we tested eight candidate ADCs for their influence on macrophages by measuring nitric oxide (NO) production and cell viability.

Single-walled carbon nanotubes induce cell death and transcription of TNF-α in macrophages without affecting nitric oxide production.

Single-walled carbon nanotubes (SWCNTs) are potent nanomaterials that have diverse shapes and features. The utilization of these molecules for drug delivery is being investigated; thus, it is important to determine whether they alter immune responses against pathogens. In this study, we show that macrophages treated with a mixture of lipopolysaccharide and SWCNTs produced normal levels of nitric oxide and inducible nitric oxide synthase mRNA.