Publications by authors named "Kyoko Kajimoto"

Purpose: Prenatal stress affects the hippocampal structure and function in pups. Maternal chewing ameliorates hippocampus-dependent cognitive impairments induced by prenatal stress. In this study, we investigated hippocampal microglia-mediated neuroinflammation in pups of dams exposed to prenatal stress with or without chewing during gestation.

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Article Synopsis
  • The study investigates how maternal chewing may influence the negative effects of prenatal stress on the behavior and brain chemistry of mouse offspring.
  • Pregnant mice were subjected to stress through restraint and some were given a chewing object; their offspring were later tested for behavioral changes and brain protein levels.
  • Results showed that maternal chewing helped reduce anxiety and cognitive impairments in pups, suggesting it positively impacts brain health and serotonin levels related to prenatal stress.
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Long-term tooth loss is associated with the suppression of hippocampal neurogenesis and impairment of hippocampus-dependent cognition with aging. The morphologic basis of the hippocampal alterations, however, remains unclear. In the present study, we investigated whether tooth loss early in life affects the hippocampal ultrastructure in senescence-accelerated mouse prone 8 (SAMP8) mice, using transmission electron microscopy.

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Yokukansan (YKS) is a traditional Japanese herbal medicine. It has been currently applied for treating behavioral and psychological symptoms of dementia in Japan. We investigated the effect of YKS on learning ability, hippocampal cell proliferation, and neural ultrastructural features in senescence-accelerated mouse prone 8 (SAMP8), a proposed animal model of Alzheimer's disease.

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