Publications by authors named "Kyoka Sugino"
Acta Neuropathol Commun
November 2023
Article Synopsis
- * Comprehensive analysis showed both primary and recurrent tumors had IDH2 and TP53 mutations, alongside deletions and amplifications of other key genes, indicating significant genetic alterations driving tumor growth.
- * Researchers developed a mouse model from the recurrent tumor, revealing that specific gene alterations may enhance tumor growth and could serve as potential targets for new treatments in IDH2-mutant astrocytoma.
Clin Cancer Res
January 2024
Article Synopsis
- The 2021 WHO classification of CNS tumors combines histopathology and molecular profiling to effectively differentiate between adult malignant brain tumors, particularly gliomas and primary CNS lymphomas (PCNSL).
- A new intraoperative integrated diagnostic (i-ID) system has been developed that enhances traditional frozen-section diagnosis with a qPCR-based genotyping assay, crucial for therapeutic decision-making.
- After testing the i-ID system on 101 patients, it showed high reliability, matching permanent diagnoses in nearly all cases, thus proving to be a valuable tool for accurate classification of adult malignant CNS tumors.
