Publications by authors named "Kyogo Kobayashi"
Article Synopsis
- Researchers studied how the brain's hippocampus adapts to environmental changes, specifically focusing on neuron activity in response to fear conditioning in mice.
- They found that while overall neuron activity changed with fear experiences, a small group of "environment cells" consistently responded to specific environments regardless of these experiences.
- This suggests that environment cells help maintain a stable representation of different surroundings, even when significant events occur, and reveals the varied roles of different neuron types in the hippocampus.
Unveiling the molecular and cellular mechanisms underlying memory has been a challenge for the past few decades. Although synaptic plasticity is proven to be essential for memory formation, the significance of "single-cell memory" still remains elusive. Here, we exploited a primary culture system for the analysis of C.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS patients, although the mechanisms by which decreased dynactin 1 levels cause neurodegeneration have yet to be elucidated. The accumulation of autophagosomes in degenerated motor neurons is another key pathological feature of sporadic ALS.
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