Publications by authors named "Kylie Nennig"
Article Synopsis
- - Understanding how viruses like human pegivirus (HPgV) evade host immunity can reveal new aspects of the immune system; HPgV infects about 15% of people but usually doesn't cause disease.
- - Researchers developed a mouse-adapted version of a pegivirus from rats (maPgV) that established a chronic infection in laboratory mice, lasting over 300 days without causing illness, similar to HPgV behavior in humans.
- - The study revealed that type-I interferon plays a pro-viral role in chronic infections and identified various ways an immune system can counter PgV, suggesting both shared and unique strategies among persistent viruses; maPgV provides a new model to explore these infections further.
Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR-knockout screens with multiple arteriviruses. Using a panel of cell lines and divergent arteriviruses, we demonstrate that FcRn is required for the entry step of arterivirus infection and serves as a molecular barrier to arterivirus cross-species infection.
View Article and Find Full Text PDFMouse models of viral infection play an especially large role in virology. In 1960, a mouse virus, lactate dehydrogenase-elevating virus (LDV), was discovered and found to have the peculiar ability to evade clearance by the immune system, enabling it to persistently infect an individual mouse for its entire lifespan without causing overt disease. However, researchers were unable to grow LDV in culture, ultimately resulting in the demise of this system as a model of failed immunity.
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