Publications by authors named "Kylee McManus"
Tumor agnostic ultrasmall nanoprobes for fluorescence-guided surgical resection in peritoneal metastasis.
Eur J Nucl Med Mol Imaging
October 2024
Article Synopsis
- Surgical excision of metastases is crucial for treating peritoneal carcinomatosis, and the success of this procedure largely depends on completely removing the tumor; researchers are exploring the use of novel fluorescent probes to enhance surgical outcomes.
- In this study, ultrasmall porous silica nanoparticles (UPSN) were developed and tested in mice with colorectal and pancreatic cancers, demonstrating effective tumor targeting and imaging capabilities during surgery.
- Results showed that the UPSN, particularly with Cy5 dye, provided superior tumor visibility and safety compared to existing imaging agents, indicating their potential as a valuable tool for improving the precision of tumor resections.