Publications by authors named "Kyle Yetsko"
Article Synopsis
- Phenylalanine ammonia lyase (PAL) converts phenylalanine to transcinnamic acid (TCA), but TCA inhibits PAL's activity over time, though adding bovine serum albumin (BSA) can prevent this inhibition by binding TCA.
- In pre-formulation studies, PAL shows optimal activity at pH 8.5, which is necessary to retain its function in the gastrointestinal tract (g.i.t), and a specific buffer with BSA can maintain this activity even under simulated digestive conditions.
- The research revealed that PAL cannot metabolize phenylalanine dipeptides, shedding light on previous low efficacy of PAL in treating phenylketonuria and informing the design of a more effective PAL microcaps
