The Rv2633c protein of is a non-heme di-iron catalase with a possible role in defenses against oxidative stress.

The gene in is rapidly up-regulated after macrophage infection, suggesting that is involved in pathogenesis. However, the activity and role of the Rv2633c protein in host colonization is unknown. Here, we analyzed the Rv2633c protein sequence, which revealed the presence of an HHE cation-binding domain common in hemerythrin-like proteins.