Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients.

Objective: To determine whether initiating saline nasal irrigation after COVID-19 diagnosis reduces hospitalization and death in high-risk outpatients compared with observational controls, and if irrigant composition impacts severity.

Methods: Participants 55 and older were enrolled within 24 hours of a + PCR COVID-19 test between September 24 and December 21, 2020. Among 826 screened, 79 participants were enrolled and randomly assigned to add 2.

Effect of axially projected oligothiophene pendants and nitro-functionalized diimine ligands on the lowest excited state in cationic Ir(III) bis-cyclometalates.

The novel terthiophene (3T) oligomer 6 and a series of cationic Ir(III) bis-cyclometalates [Ir(C^N)(2)(N^N)]PF(6) 9-12 were prepared. The synthesis, characterization, electrochemical, and photophysical properties are reported. The cyclometalating ligands (C^N) are 2-phenylpyridinato (ppy) or the 3T oligomer (3T-ppy), asymmetrically capped in the 5 and 5" positions with the ppy and mesityl groups.

Optical response of a cyclometalated iridium(III) hydrazino complex to carbon dioxide: generation of a strongly luminescent iridium(III) carbazate.

A system pairing the luminescent core of [Ir(ppy)(2)L(2)](+) (ppy = 2-phenylpyridine) with simple hydrazino ancillary ligands (L = N(2)H(4)) has been prepared for the direct optical detection of carbon dioxide (CO(2)). Silver-assisted and silver-free techniques were used for the successful introduction of N(2)H(4) into the [Ir(ppy)(2)Cl](2) coordination sphere at room temperature to give the corresponding biscyclometalated iridium(III) hydrazino species as either a CF(3)SO(3)(-) (OTf(-), 2a) or Cl(-) (2b) salt. The silver-free route was accomplished by the direct replacement of the ligated Cl(-) using a slight excess of hydrazine.