Publications by authors named "Kyle Nguyen-Ngo"
Article Synopsis
- Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder linked to abnormal changes in the FMR1 gene, leading to various symptoms, including sleep disruptions.
- Research using a KO mouse model showed that these mice experienced significant sleep and circadian disturbances, highlighting abnormal responses to light and changes in their sleep patterns.
- Implementing a scheduled feeding regimen improved the sleep and activity rhythms of the mice and also positively influenced their social behaviors and inflammation markers, indicating potential therapeutic strategies for managing symptoms of neurodevelopmental disorders like FXS.
The influence of light spectral properties on circadian rhythms is of substantial interest to laboratory-based investigation of the circadian system and to field-based understanding of the effects of artificial light at night. The trade-offs between intensity and spectrum regarding masking behaviors are largely unknown, even for well-studied organisms. We used a custom LED illumination system to document the response of wild-type house mice (Mus musculus) to 1-h nocturnal exposure of all combinations of four intensity levels (0.
View Article and Find Full Text PDF