Nanoclay Promotes Mouse Cranial Bone Regeneration Mainly through Modulating Drug Binding and Sustained Release.

Nanoclay (Nanosilicates, NS) is appearing as an intriguing 2D nanomaterial for bone tissue engineering with multiple proposed functions, e.g., intrinsic osteoinductivity, improving mechanical properties, and drug release capacity.

Genome-wide DNA methylation investigation of glucocorticoid exposure within buccal samples.

Aim: Glucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in stress-related disorders. Within mouse models, CpGs across the genome have been shown to be differentially methylated in response to glucocorticoid treatment, and using the Infinium 27K array, it was shown that humans given synthetic glucocorticoids had DNA methylation (DNAm) changes in blood. However, further investigation of the extent to which glucocorticoids affect DNAm across a larger proportion of the genome is needed.

Maxillomandibular Fixation and Anesthesia Management.

Maxillomandibular fixation (MMF) is a frequent issue encountered during the administration of general anesthesia. This article aims to give an overview of MMF from a surgical perspective, complications that can arise from MMF, anesthesia management strategies in MMF cases, and perhaps most importantly, an overview of how to release a patient from MMF in an emergency. Although not encompassing all situations and variables, these topics are covered in a manner that can be easily incorporated into the anesthetist's practice.

A Review of Dental Anatomy and Dental Injury Associated With Anesthesia.

Dental injury during airway management is a common complication encountered during the administration of general anesthesia. This article gives an overview of the frequency of dental injuries, dental anatomy, conditions that increase the risk of dental injury, and mechanism of injury, as well as discusses injury management and avoidance of dental trauma. Although this article does not encompass all situations and variables, it covers these topics in a useful and easily remembered manner that the anesthetist can easily incorporate into practice.

Use of Intraoperative Navigation for Minimally Invasive Retrieval of a Broken Dental Needle.

This report describes a case of needle breakage during an inferior alveolar nerve block to perform a restorative dental procedure on a 13-year-old patient. The needle was removed in a minimally invasive fashion using a Medtronic StealthStation S7 surgical navigation system and custom interocclusal splint to allow for stable, identically repeatable positioning of the mandible. This report adds another example of the utility of image-guided surgery for the removal of foreign bodies from the head and neck region in a minimally invasive fashion.