Publications by authors named "Kyle Kentch"
Mice are a valuable model for elegant studies of complex, system-dependent diseases, including pulmonary diseases. Current tools to assess lung function in mice are either terminal or lack accuracy. We set out to develop a low-cost, accurate, head-out variable-pressure plethysmography system to allow for repeated, nonterminal measurements of lung function in mice.
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- Hepatic lipid buildup in obesity leads to increased hyperinsulinemia and insulin resistance, affecting liver function.
- Hepatocyte depolarization reduces vagal nerve firing and heightens GABA release, contributing to hyperinsulinemia.
- Altering hepatic GABA release can improve insulin sensitivity and mitigate glucoregulatory issues in obesity, with implications for type 2 diabetes risk.
Non-Mammalian Vertebrates: Distinct Models to Assess the Role of Ion Gradients in Energy Expenditure.
Front Endocrinol (Lausanne)
September 2017
Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H), the sarcoplasmic reticulum (Ca), and the plasma membrane (Na/K). The potential energy of these gradients can be used to perform work (e.
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