Publications by authors named "Kyle D Spencer"
Article Synopsis
- - Prebiotic galactooligosaccharides (GOS) have been shown to lower anxiety-like behaviors in both mice and humans, but the underlying biological processes are not fully understood yet.
- - In a study with C57BL/6 mice, GOS supplementation decreased anxiety behaviors and specific inflammatory gene expressions in the brain, alongside changes in gut bacteria and serum metabolite levels.
- - Notably, the metabolite methyl-indole-3-acetic acid (methyl-IAA), produced from bacterial metabolism, was linked to reduced anxiety; administering methyl-IAA directly also lowered anxiety-like behavior and inflammation in brain cells.
Motivation: IntLIM uncovers phenotype-dependent linear associations between two types of analytes (e.g. genes and metabolites) in a multi-omic dataset, which may reflect chemically or biologically relevant relationships.
View Article and Find Full Text PDFPurpose: Commensal microbes are impacted by stressor exposure and are known contributors to cognitive and social behaviors, but the pathways through which gut microbes influence stressor-induced behavioral changes are mostly unknown. A murine social stressor was used to determine whether host-microbe interactions are necessary for stressor-induced inflammation, including neuroinflammation, that leads to reduced cognitive and social behavior.
Methods: C57BL/6 male mice were exposed to a paired fighting social stressor over a 1 hr period for 6 consecutive days.