Publications by authors named "Kyle D Pires"
Article Synopsis
- - Colchicine is increasingly being used to treat cardiovascular diseases but can be very dangerous in overdose situations.
- - Overdosing on colchicine causes direct damage to heart cells, which can result in severe heart failure.
- - The case study discusses a patient who experienced a colchicine overdose and required advanced life support, showcasing the difficulties in managing such emergencies.
Article Synopsis
- The study investigates the osmol gap in patients diagnosed with alcoholic ketoacidosis, which is often confused with toxic alcohol poisoning due to similar osmol gap values.
- Researchers analyzed 24 years of data and established criteria to accurately identify alcoholic ketoacidosis cases, resulting in the inclusion of 55 patients, mostly middle-aged men.
- Findings revealed a median osmol gap of 27, with a significant proportion having osmol gaps that could suggest toxic alcohol poisoning, highlighting the need for careful differentiation in diagnosing these conditions.
A 22-kg female in early childhood with a history of reactive airway disease presented to a paediatric emergency department with acute shortness of breath, tachypnoea and wheezing. Despite treatment with albuterol and corticosteroids, her bronchospasm persisted, prompting the administration of terbutaline. The patient received 220 mcg (10 mcg/kg) terbutaline intravenously, followed immediately by an inadvertent supratherapeutic intravenous dose of 10 000 mcg (454.
View Article and Find Full Text PDFBupropion is a substituted cathinone (β-keto amphetamine) norepinephrine/dopamine reuptake inhibitor andnoncompetitive nicotinic acetylcholine receptor antagonist that is frequently used to treat major depressive disorder. Bupropion overdose can cause neurotoxicity and cardiotoxicity, the latter of which is thought to be secondary to gap junction inhibition and ion channel blockade. We report a patient with a confirmed bupropion ingestion causing severe cardiotoxicity, for whom prophylactic veno-arterial extracorporeal membrane oxygenation (ECMO) was successfully implemented.
View Article and Find Full Text PDFMinding the osmol gap: a sentinel event and subsequent laboratory investigation.
Clin Toxicol (Phila)
November 2023
Introduction: Many hospitals are unable to determine toxic alcohol concentrations in a clinically meaningful time frame. Thus, clinicians use surrogate markers when evaluating potentially poisoned patients.
Index Case: A patient presented after an intentional antifreeze (ethylene glycol) ingestion with an osmol gap of -10.