Thermoresponsive Self-Immolative Polyglyoxylamides.

Thermoresponsive polymers with lower critical solution temperatures (LCSTs) are of significant interest for a wide range of applications from sensors to drug delivery vehicles. However, the most widely investigated LCST polymers have nondegradable backbones, limiting their applications or in the environment. Described here are thermoresponsive polymers based on a self-immolative polyglyoxylamide (PGAM) backbone.