Phosphate is a predominately intracellular anion that has several key roles in normal cellular functions. Derangements in serum phosphate concentration occur frequently during critical illness, particularly hypophosphataemia, which has been reported in up to 75% of Intensive Care Unit (ICU) patients. The association between hypophosphataemia and ICU outcomes reported in the literature are conflicting and and subject to substantial confounding.
View Article and Find Full Text PDFObjective: Frequent measurement of creatinine by point-of-care testing (POCT) may facilitate the earlier detection of acute kidney injury (AKI) in critically ill patients. However, no robust data exist to confirm its equivalence to central laboratory testing. We aimed to conduct a multicenter study to compare POCT with central laboratory creatinine (CrC) measurement.
View Article and Find Full Text PDFIntroduction: In critically ill patients undergoing continuous renal replacement therapy (CRRT), a positive fluid balance (FB) is associated with adverse outcomes. However, current FB management practices in CRRT patients are poorly understood. We aimed to study FB and its components in British and Australian CRRT patients to inform future trials.
View Article and Find Full Text PDFPurpose: A positive fluid balance (FB) is associated with harm in intensive care unit (ICU) patients with acute kidney injury (AKI). We aimed to understand how a positive balance develops in such patients.
Methods: Multinational, retrospective cohort study of critically ill patients with AKI not requiring renal replacement therapy.
Objective: The overall objective of this scoping review is to assess the extent of the literature related to the fluid management of critically ill patients with acute kidney injury (AKI).
Introduction: AKI is common in critically ill patients where fluid therapy is a mainstay of treatment. An association between fluid balance (FB) and adverse patient-centred outcomes in critically ill patients with AKI regardless of severity has been demonstrated.
Purpose: The Acute Disease Quality Initiative (ADQI) Workgroup recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 and Kidney Disease Improving Global Outcomes (KDIGO) AKI criteria. This study aims to describe the epidemiology of SA-AKI.
Methods: This is a retrospective cohort study carried out in 12 intensive care units (ICUs) from 2015 to 2021.
Introduction: The effect of continuous renal replacement therapy (CRRT) on renal function is poorly understood. However, the initiation of CRRT may induce oliguria. We aimed to investigate the impact of CRRT commencement on urine output (UO).
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