Publications by authors named "Kyle C White"

Phosphate is a predominately intracellular anion that has several key roles in normal cellular functions. Derangements in serum phosphate concentration occur frequently during critical illness, particularly hypophosphataemia, which has been reported in up to 75% of Intensive Care Unit (ICU) patients. The association between hypophosphataemia and ICU outcomes reported in the literature are conflicting and and subject to substantial confounding.

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Article Synopsis
  • Critically ill patients with bloodstream infections (BSIs) who experience hypothermia are at a higher risk of death, but the impact of rewarming rates on their outcomes is not well understood.
  • In a study involving 3951 ICU admissions, researchers found that 8.4% of hypothermic patients had temperatures below 34.9°C, and lower temperatures were linked to higher severity of illness and a greater need for organ support.
  • The 90-day case-fatality rate was 22.9% overall, with significantly higher rates among those with lower temperatures; faster rewarming was associated with lower mortality rates even after accounting for illness severity and comorbidities.
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  • Doctors studied how hydrocortisone, a medicine, is used for patients with septic shock in 12 hospitals to see if its use changed after a big research trial called the ADRENAL trial.
  • They found that more patients started getting hydrocortisone after the trial was published, showing an increase from 28% to 43% over time.
  • The study showed that the change in how often hydrocortisone was given was significant during two different time periods: right after the trial was published and the transition period before that.
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Objective: Frequent measurement of creatinine by point-of-care testing (POCT) may facilitate the earlier detection of acute kidney injury (AKI) in critically ill patients. However, no robust data exist to confirm its equivalence to central laboratory testing. We aimed to conduct a multicenter study to compare POCT with central laboratory creatinine (CrC) measurement.

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  • Hypophosphatemia is frequently observed in critically ill patients admitted to Intensive Care Units (ICUs), with a study examining its prevalence and outcomes in Queensland, Australia between 2015 and 2021.
  • Out of 89,776 patients, 68,699 were included, and 34.2% experienced hypophosphatemia, typically identified on the second day of ICU stay and resolved within three days.
  • The severity of hypophosphatemia correlated with increased 90-day mortality rates, with moderate and severe cases showing significantly higher fatality risks compared to those without hypophosphatemia.
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Introduction: In critically ill patients undergoing continuous renal replacement therapy (CRRT), a positive fluid balance (FB) is associated with adverse outcomes. However, current FB management practices in CRRT patients are poorly understood. We aimed to study FB and its components in British and Australian CRRT patients to inform future trials.

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Purpose: A positive fluid balance (FB) is associated with harm in intensive care unit (ICU) patients with acute kidney injury (AKI). We aimed to understand how a positive balance develops in such patients.

Methods: Multinational, retrospective cohort study of critically ill patients with AKI not requiring renal replacement therapy.

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Objective: The overall objective of this scoping review is to assess the extent of the literature related to the fluid management of critically ill patients with acute kidney injury (AKI).

Introduction: AKI is common in critically ill patients where fluid therapy is a mainstay of treatment. An association between fluid balance (FB) and adverse patient-centred outcomes in critically ill patients with AKI regardless of severity has been demonstrated.

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Purpose: The Acute Disease Quality Initiative (ADQI) Workgroup recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 and Kidney Disease Improving Global Outcomes (KDIGO) AKI criteria. This study aims to describe the epidemiology of SA-AKI.

Methods: This is a retrospective cohort study carried out in 12 intensive care units (ICUs) from 2015 to 2021.

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Introduction: The effect of continuous renal replacement therapy (CRRT) on renal function is poorly understood. However, the initiation of CRRT may induce oliguria. We aimed to investigate the impact of CRRT commencement on urine output (UO).

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