Publications by authors named "Kyle Bruns"
Article Synopsis
- Tumor-targeting antibodies (tAbs) show limited effectiveness in solid tumors, relying on the interaction with Fc receptor-expressing immune cells like tumor-associated macrophages (TAM) and neutrophils (TAN) to function properly.
- The study reveals that myeloid cells utilize a process called antibody-dependent trogocytosis (ADT), which can lead to tumor cell death only under specific conditions: high levels of tumor antigens and a sufficient number of effector cells.
- Sublethal ADT can help tumor cells escape treatment by removing important antibody-target complexes and simultaneously enhancing tumor-specific immune responses, highlighting potential targets for improving cancer therapies.
