Encapsulation of hydrophobically ion-paired teduglutide in nanoemulsions: Effect of anionic counterions.

This study presents a novel method for encapsulating the bioactive peptide teduglutide to enhance its oral bioavailability using O/W nanoemulsion (NE). Recombinant teduglutide (rTGT), produced in E. coli with 93 % purity, was hydrophobically modified through ion-pairing with phytic acid (PA) and sodium dodecyl sulfate (SDS).

Machine learning identification of edible vegetable oils from fatty acid compositions and hyperspectral images.

Hyperspectral imaging analysis combined with machine learning was applied to identify eight edible vegetable oils, and its classification performance was compared with the chemical method based on fatty acid compositions. Furthermore, the degree of adulteration in vegetable oils was quantitatively investigated using machine learning-enabled hyperspectral approaches. The hyperspectral absorbance spectra of palm oil with a high degree of saturation were distinctly different from those of the other liquid oils.

Enzymatic synthesis and characterization of novel lipophilic inotodiol-oleic acid conjugates.

In this study, we establish an efficient enzymatic approach for producing novel inotodiyl-oleates (IOs) from pure inotodiol and oleic acid to improve the properties of inotodiol. For the esterification between inotodiol and oleic acid, CALA and n-hexane were the optimal biocatalyst and solvents for forming IOs with 80.17% conversion yield.

Relationships between Instrumental and Sensory Quality Indices of Shine Muscat Grapes with Different Harvesting Times.

The effects of instrumental quality indices on the sensory properties of Shine Muscat grapes harvested 16, 18, 20, and 22 weeks after full bloom (WAFB) were investigated. The berries harvested at 20 and 22 WAFB gained higher sweetness scores than those harvested at 16 and 18 WAFB, showing similar trends to that of total soluble solids (TSS) content. The sourness, astringency, and firmness scores were not significantly different among the samples.

Physical, chemical, and biological characterization of ginsenoside F1 incorporated in nanostructured lipid carrier.

This study was aimed to determine the physical property and thermodynamic stability of nanostructured lipid carrier suspension incorporating ginsenoside F1 (GF1_NLC), and to evaluate its transport and antioxidant properties. GF1_NLC suspension possessed spherical particles with an average size of 98.9 nm, and the encapsulation efficiency reached approximately 90%.

Solid Fat Replacement with Canola Oil-Carnauba Wax Oleogels for Dairy-Free Imitation Cheese Low in Saturated Fat.

Canola oil was structured into oleogels with different amounts of carnauba wax, and their processing performances were assessed as an alternative to solid fat for imitation cheese low in saturated fat. The contents of solid fat in the oleogels were less vulnerable to the change in temperature than the palm oil. The replacement of palm oil with oleogels produced cheese samples with harder and more cohesive/chewy textures.

Characterization of phase and diffusion behaviors of oil, surfactant, and co-surfactant ternary systems for lipid-based delivery carriers.

The phase and diffusion characteristics of ternary mixture (oil, surfactant, and co-surfactant) were investigated for their utilization as a precursor for the fabrication of lipid-based delivery carriers. Different types of phases (W/O microemulsion, bicontinuous, liquid crystal, gel and O/W conventional emulsion phases) were generated depending on the content of the co-surfactant aqueous solution. A suspension with the smallest lipid particle was obtained from the bicontinuous phase, followed by the W/O microemulsion, liquid crystal, O/W conventional emulsion, and gel.

The thermal, rheological, and structural characterization of grapeseed oil oleogels structured with binary blends of oleogelator.

Combination of oleogelators has recently started to receive scientific attention since single oleogelator may not adequately compensate for the diverse roles of solid fat in a complicated food system. In this study, grapeseed oil oleogels were prepared with candelilla wax (CDW) and glyceryl monostearate (GMS) blends at varying mass ratios (100:0, 75:25, 50:50, 25:75, and 0:100 [w/w]), and their physicochemical characteristics were characterized in terms of thermal, rheological, and microstructural properties. The oleogel with CDW and GMS at a blending ratio of 75 and 25 (CDW-75:GMS-25) exhibited the lowest melting point, implying a eutectic behavior.

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs.

The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoated one over the whole pH ranges and improved encapsulation efficiency.

Bioengineered vocal fold mucosa for voice restoration.

Patients with voice impairment caused by advanced vocal fold (VF) fibrosis or tissue loss have few treatment options. A transplantable, bioengineered VF mucosa would address the individual and societal costs of voice-related communication loss. Such a tissue must be biomechanically capable of aerodynamic-to-acoustic energy transfer and high-frequency vibration and physiologically capable of maintaining a barrier against the airway lumen.

Dynamic light scattering-based method to determine primary particle size of iron oxide nanoparticles in simulated gastrointestinal fluid.

Simple dynamic light scattering (DLS)-based methodologies were developed to determine primary particle size distribution of iron oxide particles in simulated gastrointestinal fluid. Iron oxide particles, which easily agglomerate in aqueous media, were converted into dispersed particles by modification of surface charge using citric acid and sodium citrate. After the modification, zeta-potential value decreased to -40mV at pH 7.

Effect of aqueous pH and electrolyte concentration on structure, stability and flow behavior of non-ionic surfactant based solid lipid nanoparticles.

The effects of pH and electrolyte concentration on the structure evolution, polymorphism, flow behavior and stability of solid lipid nanoparticles (SLNs), stabilized by the food-grade non-ionic surfactant Tween 80, were investigated. Development of a lipid crystal was governed by thermodynamically stable β- and β'-subunits and relative crystallinity decreased with increasing pH and electrolyte concentration. Aqueous stability and dispersibility increased with increasing pH and decreased with increasing electrolyte concentration.

Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect.

The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500 mg/kg body weight for 8 weeks.