Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis.

Metastasis is the primary cause of a large number of cancer-associated deaths. By portraying the precise environment of the metastasis process , the microfluidic system provides useful insights on the mechanisms underlying cancer cell migration, invasion, colonization, and the procurement of supplemental nutrients. However, current metastasis models are biased in studying blood vessel-based metastasis pathways and thus the understanding of lymphatic metastasis is limited which is also closely related to the inflammatory system.

Subtyping of Magnetically Isolated Breast Cancer Cells Using Magnetic Force Microscopy.

Circulating tumor cell (CTC) which recently arisen as potential sources for monitoring and characterizing non-haematologic cancers and their metastatic derivatives. Immunomagnetic microbeads and magnetic nanoparticles (MNPs) have been extensively explored to isolate CTCs from blood samples. However, MNPs attached on the membrane protein are interrupted further analysis to distinguish the cancer subtype by consumption or blocking the target surface marker.

Silver Nanoparticle Modified Electrode Covered by Graphene Oxide for the Enhanced Electrochemical Detection of Dopamine.

Several neurological disorders such as Alzheimer's disease and Parkinson's disease have become a serious impediment to aging people nowadays. One of the efficient methods used to monitor these neurological disorders is the detection of neurotransmitters such as dopamine. Metal materials, such as gold and platinum, are widely used in this electrochemical detection method; however, low sensitivity and linearity at low dopamine concentrations limit the use of these materials.

Selective isolation and noninvasive analysis of circulating cancer stem cells through Raman imaging.

Circulating cancer stem cells (CCSCs), a rare circulating tumor cell (CTC) type, recently arose as a useful resource for monitoring and characterizing both cancers and their metastatic derivatives. However, due to the scarcity of CCSCs among hematologic cells in the blood and the complexity of the phenotype confirmation process, CCSC research can be extremely challenging. Hence, we report a nanoparticle-mediated Raman imaging method for CCSC characterization which profiles CCSCs based on their surface marker expression phenotypes.

Nanostructure Modified Microelectrode for Electrochemical Detection of Dopamine with Ascorbic Acid and Uric Acid.

Dopamine (DA) is one kind of neurotransmitter in central nervous system which is indicator of neural disease. For this reason, determination of DA concentration in central nervous system is very important for early diagnosis of neural disease. In this study, we designed micro electrode array and fabricated by MEMS technology.

In situ label-free quantification of human pluripotent stem cells with electrochemical potential.

Conventional methods for quantification of undifferentiated pluripotent stem cells such as fluorescence-activated cell sorting and real-time PCR analysis have technical limitations in terms of their sensitivity and recyclability. Herein, we designed a real-time in situ label-free monitoring system on the basis of a specific electrochemical signature of human pluripotent stem cells in vitro. The intensity of the signal of hPSCs highly corresponded to the cell number and remained consistent in a mixed population with differentiated cells.

In situ monitoring of doxorubicin release from biohybrid nanoparticles modified with antibody and cell-penetrating peptides in breast cancer cells using surface-enhanced Raman spectroscopy.

In situ monitoring of drug release in cancer cells is very important for real-time assessment of drug release dynamics in chemotherapy. In this study, we report label-free in situ monitoring and control of intracellular anti-cancer drug delivery process using biohybrid nanoparticles based on surface-enhanced Raman spectroscopy (SERS) for the first time. Each biohybrid nanoparticle consisted of gold nanoparticle, cell-penetrating peptide (Tat peptide), and cancer-targeting antibody to increase the efficacy of the anti-cancer drug delivery with specific targeting and increased uptake rate.

Monitoring of black carbon concentration at an inland rural area including fixed sources in Korea.

We monitored black carbon (BC) concentration for 6months to understand the characteristics of atmospheric aerosols of an inland rural area in Korea. A multi-angle absorption photometer was used to continuously monitor the BC concentration, which was compared with elemental carbon (EC) concentration measured by an OC/EC Analyzer. For the atmospheric aerosols less than 10μm, size distributions were measured using both an optical particle counter and a scanning mobility particle sizer.