Publications by authors named "Kyein San Loon"
Article Synopsis
- The Bcl-2 protein is crucial for regulating programmed cell death, but its expression in chondrocytes and its role in related disorders is not yet fully understood, prompting interest in Chlorogenic acid (CGA) as a potential therapeutic agent.
- In experiments, researchers observed that reducing Bcl-2 levels led to increased cell death and dysfunction, while enhancing Bcl-2 expression decreased these effects, highlighting its importance in apoptosis and inflammation pathways in chondrocytes.
- CGA treatment was found to mitigate the negative effects of decreased Bcl-2, promoting cell proliferation by preventing the release of pro-apoptotic factors and ultimately improving chondrocyte health.
There is evidence to suggest that microRNA-140-5p (miR-140), which acts as a suppressor, is often elevated and has a role in various malignancies. Nevertheless, neither the function nor the mechanisms in chondrocytes linked with bone disorders, e.g.
View Article and Find Full Text PDF