Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors.

Caspases are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation. Complementary to genetic approaches, small-molecule probes have emerged as useful tools for modulating caspase activity. However, due to the high sequence and structure homology of all 12 human caspases, achieving selectivity remains a central challenge for caspase-directed small-molecule inhibitor development efforts.

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors.

Caspases are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation. Complementary to genetic approaches, small-molecule probes have emerged as useful tools for modulating caspase activity. However, due to the high sequence and structure homology of all twelve human caspases, achieving selectivity remains a central challenge for caspase-directed small-molecule inhibitor development efforts.

Green Chemistry for the Transformation of Chlorinated Wastes: Catalytic Hydrodechlorination on Pd-Ni and Pd-Fe Bimetallic Catalysts Supported on SiO.

Monometallic catalysts based on Fe, Ni and Pd, as well as bimetallic catalysts based on Fe-Pd and based on Ni-Pd supported on silica, were synthesized using a sol-gel cogelation process. These catalysts were tested in chlorobenzene hydrodechlorination at low conversion to consider a differential reactor. In all samples, the cogelation method allowed very small metallic nanoparticles of 2-3 nm to be dispersed inside the silica matrix.

The effects of random and seasonal environmental fluctuations on optimal harvesting and stocking.

We analyze the harvesting and stocking of a population that is affected by random and seasonal environmental fluctuations. The main novelty comes from having three layers of environmental fluctuations. The first layer is due to the environment switching at random times between different environmental states.

Harvesting and seeding of stochastic populations: analysis and numerical approximation.

We study an ecosystem of interacting species that are influenced by random environmental fluctuations. At any point in time, we can either harvest or seed (repopulate) species. Harvesting brings an economic gain while seeding incurs a cost.

Harvesting of interacting stochastic populations.

We analyze the optimal harvesting problem for an ecosystem of species that experience environmental stochasticity. Our work generalizes the current literature significantly by taking into account non-linear interactions between species, state-dependent prices, and species seeding. The key generalization is making it possible to not only harvest, but also 'seed' individuals into the ecosystem.

Assessing measurement properties of two single-item general health measures.

Background: Multi-item health status measures can be lengthy, expensive, and burdensome to collect. Single-item measures may be an alternative. We compared measurement properties of two single-item, general self-rated health (GSRH) questions to assess how well they captured information in a validated, multi-item instrument.