Major ABO Incompatibility in Non-Myeloablative Hematopoietic Stem Cell Transplant for Sickle Cell Disease-Not an Insurmountable Obstacle.

With advances in conditioning strategies and graft-versus-host disease (GvHD) prevention, hematopoietic stem cell transplantation (HSCT) is a safe, curative treatment option for pediatric patients with sickle cell disease (SCD). However, donor options have been limited in non-myeloablative matched sibling donor (MSD) setting by excluding recipients with major ABO blood group incompatible donors due to concern of the risk of significant complications such as pure red cell aplasia (PRCA). We present three cases of successful HSCT with major ABO incompatibility with their donors, and discuss strategies to safely expand the donor pool to include these donors.

Early Engraftment and Immune Kinetics Following Allogeneic Transplant Using a Novel Reduced-Toxicity Transplant Strategy in Children/Adolescents with High-Risk Transfusion-Dependent Thalassemia: Early Results of the ThalFAbS Trial.

Allogeneic hematopoietic stem cell transplantation is challenging for patients with transfusion-dependent thalassemia who have experienced iron overload and received chronic transfusion support. A transplantation strategy including a reduced-intensity preparative regimen and tailored immunosuppression to support donor engraftment and prevent graft-versus-host disease (GVHD) was developed for this population. The combination of a pretransplantation immunosuppression phase with reduced dosing of fludarabine/prednisone, a treosulfan-based preparative regimen with reduced cyclophosphamide dosing, and introduction of a calcineurin/methotrexate-free GVHD prophylaxis/engraftment supporting regimen with abatacept/sirolimus/antithymocyte globulin was tested.

The first attempt in synthesis, identification, and evaluation of SEPT9 inhibitors on human oral squamous carcinomas.

Septin 9 (SEPT9), a GTPase, known as the fourth cytoskeleton, is widely expressed in various cells and tissues. The functions of SEPT9 are partly similar to other cytoskeletons as a structure protein. Further, SEPT9 can interact with other cytoskeletons, participating in actin dynamics and microtubule regulation.

Temperature-dependent highly active LaCaMgAlO catalyst effect on carbon nanomaterial and hydrogen generation from polymethyl methacrylate plastic.

The increasing accumulation of waste polymethyl methacrylate (PMMA) plastics presents a significant environmental challenge, while the demand for renewable energy sources continues to rise. Thermochemical recycling is a prospective technique for converting waste plastics into high-value chemicals, both economically and environmentally. In this work, the catalytic pyrolysis of waste PMMA plastics over LaCaMgAlO nanosheets (NSs) catalyst is being investigated for its potential to produce hydrogen and carbon nanotubes (CNTs) in a two-stage fixed-bed reactor.

Highly efficient oxygen carrier NiFeP (oxy) hydroxides nanoparticle embedded in N-doped porous carbon derived from bio-waste for bifunctional electrocatalysts.

Developing cost-effective, readily available materials for efficient hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in water splitting is a crucial step toward enhancing the profitability and sustainability of energy conversion systems. This research introduces a novel synthesis method for NiFeP/NPC OHs from banana peel bio-waste, a method that could revolutionize the field of materials science and electrochemistry. The use of metallic phosphides, known for their excellent electrical conductivity and catalytic activity, as bifunctional catalysts, combined with the efficient synthesis of nanoporous carbons (NPC) from banana peel bio-waste (BPW), could pave the way for a new era of sustainable and cost-effective energy conversion.

Flipping Water Orientation at the Surface of Water-in-Salt and Salt-in-Water Solutions.

Salt-in-water and water-in-salt mixtures are promising for battery applications and fine-tuning of room-temperature ionic liquid (RTIL) properties. Although critical processes take place at interfaces of these systems, including charge transfer and heterogeneous catalytic reactions, the microscopic interfacial structures remain unclear. Here, we apply heterodyne-detected sum-frequency generation spectroscopy to aqueous solutions of imidazolium-based RTILs to unveil the microscopic structure of the interfaces of these solutions with air.

A double-blind randomized controlled trial of N-acetylcysteine (NAC) for the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with acute exacerbation (AECOPD) being a common sequalae which negatively impact health status, rates of hospitalization and readmission, and disease progression. N-acetylcysteine (NAC) has been studied in COPD in both stable state and acute exacerbations, which has been shown to have small beneficial effects in stable COPD, as well as AECOPD. Yet, there has been lack of study with well-designed protocol to assess the role of NAC in more objective outcomes in AECOPD.

Natural bio-waste-derived 3D N/O self-doped heteroatom honeycomb-like porous carbon with tuned huge surface area for high-performance supercapacitor.

Supercapacitor electrodes (SCs) of carbon-based materials with flexible structures and morphologies have demonstrated excellent electrical conductivity and chemical stability. Herein, a clean and cost-effective method for producing a 3D self-doped honeycomb-like carbonaceous material with KOH activation from bio-waste oyster shells (BWOSs) is described. A remarkable performance was achieved by the excellent hierarchical structured carbon (HSC-750), which has a large surface area and a reasonably high packing density.

Bimetal-organic frameworks derived redox-type composite materials for high-performance energy storage.

Electrodes and electroactive materials are crucial components in the development of supercapacitors due to their geometric properties. In this study, bimetal-organic frameworks (Bi-MOFs, ZIF-8@ZIF-67) were utilized as electrode materials for a high-performance hybrid supercapacitor (HSC) by designing a novel synthesis of metallic carbonate hydroxide/oxides. In particular, the Bi-MOFs function as a sacrificial precursor in the synthesis of hollow NiMn(CO)·0·.

Characteristics of hydrogen energy yield in steam gasification of coffee residues.

Coffee residues (CRs) were gasified using a laboratory-scale fluidized bed gasifier with an air/steam mixture as the carrier gas. The gasification was conducted at an equivalence ratio (ER) of 0.3, and different operation temperatures (700, 800, and 900 °C) and steam-to-biomass (S/B) ratios (0, 0.

Gut Immunomodulation with Vedolizumab prior to Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients with Inflammatory Bowel Disease.

Inborn errors of immunity (IEI) are often associated with inflammatory bowel disease (IBD). IEI can be corrected by allogeneic hematopoietic stem cell transplantation (HSCT); however, peritransplantation intestinal inflammation may increase the risk of gut graft-versus-host disease (GVHD). Vedolizumab inhibits the homing of lymphocytes to the intestine and may attenuate gut GVHD, yet its role in preventing GVHD in pediatric patients with IEI-associated IBD has not been studied.

Polylactic acid-based plastic activated NiAlO nanoparticles as highly active positive electrode materials for energy storage supercapacitor.

A simple, low-cost, and environmentally benign process for synthesizing nanostructured NiO/NiAlO on multiple kinds of carbon nanostructures (CNS) is presented. This method develops polylactic acid (PLA) based waste plastic materials for the producing CNS. These composites (NiO@NiAlO/CNS) were examined as potential electrodes in supercapacitors (SC) as they exhibit good charge/discharge reversibility and provide adequate specific capacitance values with a maximum being 1984 F/g at 0.

Recovery of aluminum from plastic packages containing aluminum by gasification.

The standing pouch, a packaging material made of multiple layers of plastic and metal, presents a significant challenge for full recycling. Gasification shows promise as a method to recover aluminum from this type of waste and convert it into energy. This study aims to evaluate the efficiency of gasification in treating aluminum-containing plastic packages, and recovering aluminum while identifying the optimal combinations of temperature and equivalence ratio (ER) to achieve the best outcomes.

Spontaneous Appearance of Triiodide Covering the Topmost Layer of the Iodide Solution Interface Without Photo-Oxidation.

Ions containing iodine atoms at the vapor-aqueous solution interfaces critically affect aerosol growth and atmospheric chemistry due to their complex chemical nature and multivalency. While the surface propensity of iodide ions has been intensely discussed in the context of the Hofmeister series, the stability of various ions containing iodine atoms at the vapor-water interface has been debated. Here, we combine surface-specific sum-frequency generation (SFG) vibrational spectroscopy with molecular dynamics simulations to examine the extent to which iodide ions cover the aqueous surface.

Surface stratification determines the interfacial water structure of simple electrolyte solutions.

The distribution of ions at the air/water interface plays a decisive role in many natural processes. Several studies have reported that larger ions tend to be surface-active, implying ions are located on top of the water surface, thereby inducing electric fields that determine the interfacial water structure. Here we challenge this view by combining surface-specific heterodyne-detected vibrational sum-frequency generation with neural network-assisted ab initio molecular dynamics simulations.

Bulklike Vibrational Coupling of Surface Water Revealed by Sum-Frequency Generation Spectroscopy.

Vibrational coupling between interfacial water molecules is important for energy dissipation after on-water chemistry, yet intensely debated. Here, we quantify the interfacial vibrational coupling strength through the linewidth of surface-specific vibrational spectra of the water's O─H (O─D) stretch region for neat H_{2}O/D_{2}O and their isotopic mixtures. The local-field-effect-corrected experimental SFG spectra reveal that the vibrational coupling between hydrogen-bonded interfacial water O─H groups is comparable to that in bulk water, despite the effective density reduction at the interface.

Intractable abdominal pain as the sole symptom of Varicella Zoster reactivation after allogeneic stem cell transplantation: brief case report and review of the literature.

After primary infection, Varicella Zoster (VZV) persists in sensory dorsal root ganglia and may be reactivated in periods of diminished T-cell immunity. Varicella Zoster reactivation post allogenic stem cell transplantation (HSCT) can be challenging to diagnose as it does not always present with characteristic skin lesions. We describe a pediatric patient who presented with isolated severe abdominal pain with no other symptoms.

Effects of various functional monomers' reaction on the surface characteristics and bonding performance of polyetheretherketone.

Purpose: Polyetheretherketone (PEEK) is a new polymeric material that has received significant attention in dentistry because of its mechanical properties, biocompatibility, and aesthetics. However, the bonding performance of PEEK to other materials is not preferable. This study aimed to analyze the variations in the surface characteristics of PEEK under the chemical action of primers containing different functional monomers or polymers and to evaluate the bonding performance of PEEK and dental cement.

Pulmonary Hemorrhage in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Single-Center Retrospective Study.

Objectives: Pulmonary hemorrhage (PH) is a serious complication posthematopoietic stem cell transplant (HSCT). In view of limited available pediatric data, we performed a retrospective study to describe epidemiology, management, and outcomes of PH post-HSCT in children in our national center.

Design: Retrospective study.

Enhancement strategies of poly(ether-block-amide) copolymer membranes for CO separation: A review.

Poly(ether-block-amide) (Pebax) membranes have become the preferred CO separation membrane because of their excellent CO affinity and robust mechanical resistance. Nevertheless, their development must be considered to overcome the typical obstacles in polymeric membranes, including the perm-selectivity trade-off, plasticization, and physical aging. This article discusses the recent enhancement strategies as a guideline for designing and developing Pebax membranes.

Facile synthesis of polyethyleneimine-modified cellulose nanocrystal/silica hybrid aerogel for CO adsorption.

Cellulose nanocrystal (CNC)/silica hybrid aerogel (CSA) was synthesized from CNC and sodium silicate hybridization using the one-step sol-gel method under atmospheric drying. At a weight ratio of CNC to silica of 1:1, the obtained CSA-1 had a highly porous network, a high specific area of 479 m g, and a CO adsorption capacity of 0.25 mmol g.

Does the Sum-Frequency Generation Signal of Aromatic C-H Vibrations Reflect Molecular Orientation?

Organic molecules with aromatic groups at the aqueous interfaces play a central role in atmospheric chemistry, green chemistry, and on-water synthesis. Insights into the organization of interfacial organic molecules can be obtained using surface-specific vibrational sum-frequency generation (SFG) spectroscopy. However, the origin of the aromatic C-H stretching mode peak is unknown, prohibiting us from connecting the SFG signal to the interfacial molecular structure.