Loss of Mickey Mouse Ears' Sign in Progressive Supranuclear Palsy.

Progressive supranuclear palsy (PSP) is the most prevalent form of degenerative atypical parkinsonism. Clinical manifestations of PSP commonly encompass deficits in vertical gaze, postural stability, akinesia, and cognitive impairment. The characteristic metabolic pattern observed in PSP through FDG PET displays hypometabolism in the midbrain, striatum, thalamus, and frontal lobe.

18 F-FDG PET/CT in Synovial Anaplastic Large Cell Lymphoma.

Anaplastic large cell lymphoma is an uncommon and aggressive form of peripheral T-cell lymphoma. Synovial anaplastic large cell lymphoma is very rare. We present PET/CT findings in a patient with synovial anaplastic large cell lymphoma.

Denosumab versus alendronate in long-term glucocorticoid users: A 12-month randomized controlled trial.

Objectives: To compare the efficacy of denosumab and alendronate on raising spine bone mineral density (BMD) in long-term glucocorticoid (GC) users.

Methods: Adult patients receiving long-term prednisolone (≥2.5 mg/day for ≥1 year) were recruited and randomized to either subcutaneous denosumab (60 mg/6 months) or oral alendronate (70 mg/week).

Switching of oral bisphosphonates to denosumab in chronic glucocorticoid users: a 12-month randomized controlled trial.

Objectives: To evaluate the effect of switching from oral bisphosphonates to denosumab on bone mineral density (BMD) in long-term glucocorticoid users.

Methods: Adult patients who were receiving long-term prednisolone (≥2.5 mg/day for ≥1 year) and oral bisphosphonates (≥2 years) were recruited.

Clinical characteristics of concurrent and sequentially presented lupus-related protein-losing enteropathy: what are their differences?

Our objective was to compare patients with concurrent and sequentially presented systemic lupus erythematosus (SLE)-related protein-losing enteropathy (PLE). Patients with history of SLE admitted for PLE were selected and their clinical, laboratory, endoscopic and imaging characteristics, treatment and outcome were analyzed. From 2001 to 2010, 21 and 27 patients had concurrent and sequentially presented SLE-related PLE, respectively, and their clinical characteristics were comparable except the following: the concurrent group had more pleural effusion (P < 0.

Protein-losing enteropathy associated with or without systemic autoimmune disease: what are the differences?

Objective: The aim of our study was to compare protein-losing enteropathy (PLE) associated with or without systemic autoimmune (SA) diseases.

Methods: Patients diagnosed with PLE were selected, and their clinical characteristics, laboratory, endoscopic and imaging characteristics, treatment, and outcome were analyzed.

Results: From 2001 to 2010, 74 patients (60 patients with SA disease) with a female predominance were diagnosed with PLE.

Childhood-onset disease carries a higher risk of low bone mineral density in an adult population of systemic lupus erythematosus.

Objective: To study the BMD of patients with SLE according to the age of disease onset.

Methods: Consecutive SLE patients were screened for BMD at the hip, lumbar spine and whole body by the dual-energy X-ray absorptiometry (DXA). Comparison was made between patients who had disease onset in childhood (<18 years) and adulthood (≥18 years).

Raloxifene for prevention of glucocorticoid-induced bone loss: a 12-month randomised double-blinded placebo-controlled trial.

Objectives: To study the efficacy of raloxifene in preventing bone mineral density (BMD) loss in women receiving long-term glucocorticoids (GC). The study took the form of a parallel-group randomised double-blinded placebo-controlled trial.

Methods: Postmenopausal women without hypercoagulability risk factors who were prevalent GC users were randomised to receive either raloxifene (60 mg/day) or placebo (1 tablet/day) on top of calcium (1000 mg/day) and calcitriol (0.

Bone mineral density and body composition in men with systemic lupus erythematosus: a case control study.

Objective: To study the bone mineral density (BMD) and body composition in men with systemic lupus erythematosus (SLE).

Methods: Consecutive male patients who fulfilled > or =4 ACR criteria for SLE and age-matched healthy men were recruited for measurement of BMD and body composition by DXA scan. Risk factors for low BMD in SLE patients were evaluated.

Raloxifene for postmenopausal women with systemic lupus erythematosus: a pilot randomized controlled study.

Objective: To study the effects of raloxifene on disease activity and bone mineral density (BMD) in postmenopausal women with systemic lupus erythematosus (SLE).

Methods: Postmenopausal women with osteopenia and inactive SLE were randomly assigned to receive either raloxifene (60 mg/day) plus elemental calcium (1,200 mg/day) or elemental calcium alone (control). Patients with a history of thromboembolism or antiphospholipid antibody positivity were excluded.

Segmental renal artery stenosis diagnosed with captopril renography in a child.

A 9-year-old girl with clinical suspicion of renovascular hypertension was referred for captopril renography. This showed a segmental abnormality when the left kidney was analyzed as two separate cortical regions of interest. Subsequent angiography confirmed stenosis in the distal mid and lower pole branches of the left renal artery.

Ictal Tc ECD SPECT in paroxysmal kinesigenic choreoathetosis.

Paroxysmal kinesigenic choreoathetosis is a rare neurologic disorder characterized by sudden attacks of brief involuntary dyskinetic movement that are precipitated by voluntary movement. A 14-year-old male who presented with frequent brief attacks of hemidystonia triggered by sudden movement is reported. Investigations, including video electroencephalogram and magnetic resonance imaging of brain, were normal.