A Novel Approach to the Isolation of Disease Markers: Quantitative Analysis of Amino Acids in Exhaled Breath Condensates from Sleep Apnea Patients with Enhanced Sampling and LC-ESI-MS.

Interest in obstructive sleep apnea is rising due to its neurocognitive and cardiovascular impacts, including systemic hypertension, myocardial infarction, and cerebrovascular events. Obstructive sleep apnea diagnosis can be suggested through symptoms like snoring, daytime sleepiness, and physical signs like increased neck circumference; however, overnight polysomnography is recommended to confirm. Exhaled breath condensate has emerged as a novel, noninvasive technique for biomarker sample collection.

Bio-inspired Surface Texture Modification as a Viable Feature of Future Aquatic Antifouling Strategies: A Review.

The imitation of natural systems to produce effective antifouling materials is often referred to as "biomimetics". The world of biomimetics is a multidisciplinary one, needing careful understanding of "biological structures", processes and principles of various organisms found in nature and based on this, designing nanodevices and nanomaterials that are of commercial interest to industry. Looking to the marine environment for bioinspired surfaces offers researchers a wealth of topographies to explore.

Serum expression of selected miRNAs in patients with laryngeal squamous cell carcinoma (LSCC).

Background: The aim of the present study was to identify specific serum miRNAs (preoperative serum samples compared to healthy controls) as potential diagnostic markers for detection in laryngeal squamous cell carcinoma (LSCC). Serum samples obtained from 66 patients with LSCC were compared with 100 healthy control subjects. Additionally, miRNA levels were evaluated to identify possible correlations with clinicopathological features.

Sense and need for power in schizophrenic patients.

Objectives: The purpose of the research was to analyze the sense of power of schizophrenic patients in relations with others, physicians, their need for power and influence as well as the sense of being able to have power and influence. Dependencies linked with the age and gender were also analyzed by comparing the study group and the control group.

Methods: The study group included 47 patients diagnosed with F20 (Schizophrenia).

Nontuberculous mycobacteria strains isolated from patients between 2013 and 2017 in Poland. Our data with respect to the global trends.

Introduction: During the last decades the prevalence of NTM infections has increased, especially in developed countries. The aim of the study was to provide an overview on all NTM isolated from clinical samples in Poland between 2013 and 2017.

Material And Methods: The study comprised 2799 clinical specimens, mostly respiratory accessed in the reference laboratory of National Tuberculosis and Lung Diseases Research Institute in Warsaw and in the Wielkopolska Center of Pulmonology and Thoracic Surgery, Poland, 2013-2017.

QuantiFERON-TB-GOLD In-Tube in patients with sarcoidosis.

Introduction: Sarcoidosis and tuberculosis (TB) are the diseases that share many similarities. Mycobacterium tuberculosis (MTB) culture results are the gold standard for the diagnosis of TB, but false positive results are not rare. The aim was to evaluate the utility of QFT in detecting latent TB infection in a group of sarcoidosis patients with negative history of TB and negative culture/BACTEC results, and checking sarcoidosis activity influence on the QFT results.

IPF and CPFE - the two different entities or two different presentations of the same disease?

In this article the co-existence of pulmonary emphysema with lung fibrosis of typical pattern and distribution for usual interstitial pneumonia (UIP) was compared with idiopathic pulmonary fibrosis (IPF) alone. Author discusses the etiopathogenesis of these diseases, differences in signaling pathways and the role of senescent cells. Moreover, clinical course, pulmonary function tests as well as main complications are reviewed.

A clinic-epidemiological study of head and neck tuberculosis - a single-center experience.

Introduction: Extrapulmonary tuberculosis (EPTB) accounts for less than 6% of all tuberculosis (TB) cases in Poland, although in other countries (European in particular) this proportion is much higher. The study was undertaken to evaluate the clinical and epidemiological differences in patients hospitalized in one of Otolaryngology Departments in Poland during 36 years.

Material And Methods: In a retrospective study, 71 patients were identified and divided into three groups according to the study period: I - 1978-1989 (30 patients, 42%), II - 1990-2001 (19 patients, 27%) and III - 2002-2013 (22 patients, 31% of all cases).

Elevated exhalation of hydrogen peroxide in patients with non-small cell lung cancer is not affected by chemotherapy.

Objectives: Reactive oxygen species, which are implicated in the process of carcinogenesis, are also responsible for cell death during chemotherapy (CHT). Therefore, the aim of the study was to evaluate exhaled HO levels in non-small cell lung cancer (NSCLC) patients before and after CHT.

Methods: Thirty patients (age 61.

Acute laryngeal dyspnea as first presentation of granulomatosis with polyangiitis.

Granulomatosis with polyangiitis (GPA) is a multi-organ disease which mostly affects lungs, kidney, and head and neck region. We report a rare case of acute laryngeal dyspnea and rapidly progressive pulmonary changes as first manifestations of disease. A 53 year-old woman presented with symptoms of two-week dyspnea, which aggravated rapidly in the preceding hours.

Clinical Mycobacterium tuberculosis isolates from the population of Łódź, Poland stimulated macrophages to the lower production of IL-12 and NO when compared to the virulent H37Rv strain.

The course of Mycobacterium tuberculosis (Mtb) infection and the outcome of clinically active tuberculosis depend on the complex interactions between the host immune system and M. tuberculosis properties. The objective of the study was to examine the virulence of local Mtb isolates from the population of Łódź in Poland.

Mycobacterium tuberculosis as a sarcoid factor? A case report of family sarcoidosis.

Patient: Male, 26 FINAL DIAGNOSIS: Sarcoidosis Symptoms: Disseminated lung parenchymal changes Medication: - Clinical Procedure: - Specialty: Pulmonology.

Objective: Rare disease.

Background: Sarcoidosis is a granulomatous inflammatory disease that is induced by unknown antigen(s) in a genetically susceptible host.

Virulence of clinical Mycobacterium tuberculosis strains in Lodz, Poland.

Setting: The transmission of tuberculosis (TB) in the population and the development of disease are determined not only by the patient's immunological status, but also by the virulence of Mycobacterium tuberculosis strains.

Objective: To examine the virulence of M. tuberculosis clinical isolates with recognised transmission collected from 2006 to 2007 in a population in Lodz, Poland.

Enhanced exhalation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with COPD exacerbation: a prospective study.

Background: Matrix metalloproteinase-9 (MMP-9) and its inhibitor tissue inhibitor of metalloproteinase-1 (TIMP-1) are involved in the pathogenesis of airway inflammation in patients with chronic obstructive pulmonary disease (COPD). However, no study so far has addressed their value as noninvasive biomarkers of airways inflammation.

Objective: To evaluate MMP-9 and TIMP-1 concentrations in the exhaled breath condensate (EBC) of patients with stable COPD and also during the exacerbation episode.

[Comparison of local and systemic inflammatory markers in patients with community-acquired pneumonia and pneumonia coexisting with lung cancer].

Background: The aim of the study was to compare the local and systemic markers of inflammatory processes in patients with community-acquired pneumonia (CAP) and in those with pneumonia coexisting with lung cancer.

Material And Methods: Seventeen patients with community-acquired pneumonia (group I), 14 patients with pneumonia and lung cancer (group II), and 24 patients with lung cancer (group III) were enrolled into the study. Sixteen healthy smokers served as a control group (group IV).

[Mycobacterium tuberculosis--intracellular pathogen. Relationship between mycobacteria and the host].

In mutual interactions between mycobacteria and the host the crucial for the elimination of the pathogen is the first phase of infection. It depends from one side on the innate immunity of the host and on the virulence of mycobacteria from the other. These not exactly well known factors of M.

[Chemical structure of Mycobacterium tuberculosis. Part II--proteins].

In this paper the structure of M. tuberculosis cell, especially mycobacterial proteins were analized. Cytoplasmatic and secretory proteins were reviewed according to their function and the role in immunological reactions.

[Chemical structure of Mycobacterium tuberculosis. Part I--lipids].

Tuberculosis is a burning health issue in the contemporary world. Recognition of mechanisms by means of which pathogenic bacilli affect host cells and their virulence factors is indispensable to developing and synthesis of new drugs and vaccines. The authors discuss groups of the most important chemical compounds from the pathological point of view, which are responsible for morbidity and virulence of tubercle bacillus.

Elevated exhalation of hydrogen peroxide and circulating IL-18 in patients with pulmonary tuberculosis.

Mycobacteria are the strong stimulators of respiratory burst, resulting in production of reactive oxygen species and nitrogen intermediates. The aim of our study was to assess the concentration of hydrogen peroxide (H(2)O(2)) in expired breath condensate (EBC) and the serum level of interleukin-18 (IL-18) in patients with active pulmonary tuberculosis (TB) before introduction of chemotherapy and after 2 months of treatment. Sixteen patients, current cigarette smokers, with advanced pulmonary TB were enrolled into the study.

Tuberculosis bacilli still posing a threat. Polymorphism of genes regulating anti-mycobacterial properties of macrophages.

One third of the earth's population is infected with Mycobacterium tuberculosis, but only 5-10% of the infected individuals will develop active disease over their lifetime. To identify the genes responsible for the variation in the human susceptibility/resistance to tuberculosis (TB) we determined the polymorphisms of three genes crucial for the function of macrophages, in TB patients and healthy controls with no past history of TB. We found no association between the polymorphisms of the NRAMP-INT4, MBL (codons 52, 54, 57) and CD14-159 genes and TB in a Caucasian Polish population.

[Comparison of oxidative stress markers in exhaled breath condensate and in serum of patients with tuberculosis and sarcoidosis].

Unlabelled: Tuberculosis and sarcoidosis represent the granulomatous diseases. The aim of the study was to compare the markers of oxidative stress: in exhaled breath condensate (EBC) and in serum of patients with tuberculosis and sarcoidosis.

Material And Methods: 19 patients with active lung tuberculosis and 15 patients with sarcoidosis were enrolled into the study.

Circulation level of matrix metalloproteinase-9 is correlated with disease severity in tuberculosis patients.

Setting: Parenchymal lung destruction accompanied by active tuberculosis is, at least in part, caused by host as well as bacillus metalloproteinases. Mycobacterium tuberculosis has been shown to stimulate MMP-9 expression in the lung of infected organisms.

Design: We have used quantitative zymography and computer-assisted image analysis to measure the levels of type IV collagenases in 20 serum samples of patients with active tuberculosis and in 23 serum samples of healthy volunteers.

Enhanced lipid peroxidation in cancer tissue homogenates in non-small cell lung cancer.

The oxidative modification of nucleic acids by reactive oxygen species may lead to malignant conversion, but its exact role in lung cancer biology is still not clear. Lipid peroxidation, a well-known index of free radicals activity, is a process of oxidative polyunsaturated acids destruction. Our study was aimed to investigate the level of lipid peroxidation ex vivo in tumor tissue and lung parenchyma obtained from patients with non-small cell lung cancer.

[The evaluation of efficacy and tolerability of salbutamol administered by nebulization in patients with stable severe bronchial asthma].

The aim of the study was the assessment of the effect of salbutamol in nebulization on ventilatory parameters and heart action in patients with stable severe well controlled bronchial asthma. The study was performed in 30 asthmatics (19 females and 11 men) with incomplete reversibility of airflow obstruction after salbutamol inhalation administered via MDI device. The mean age was 47 years, the duration of asthma--18 years.