Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF.

Serum response factor (SRF) is a master transcription factor that regulates immediate early genes and cytoskeletal remodeling genes. Despite its importance, the mechanisms through which SRF stably associates with its cognate promoter remain unknown. Our biochemical and protein-induced fluorescence enhancement analyses showed that the binding of SRF to serum response element was significantly increased by inositol polyphosphate multikinase (IPMK), an SRF cofactor.

Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice.

Autism spectrum disorders (ASD) frequently accompany macrocephaly, which often involves hydrocephalic enlargement of brain ventricles. Katnal2 is a microtubule-regulatory protein strongly linked to ASD, but it remains unclear whether Katnal2 knockout (KO) in mice leads to microtubule- and ASD-related molecular, synaptic, brain, and behavioral phenotypes. We found that Katnal2-KO mice display ASD-like social communication deficits and age-dependent progressive ventricular enlargements.

Emerging insights into transcriptional condensates.

Eukaryotic transcription, a fundamental process that governs cell-specific gene expression, has long been the subject of extensive investigations in the fields of molecular biology, biochemistry, and structural biology. Recent advances in microscopy techniques have led to a fascinating concept known as "transcriptional condensates." These dynamic assemblies are the result of a phenomenon called liquid‒liquid phase separation, which is driven by multivalent interactions between the constituent proteins in cells.

Effects of assisted aquatic movement and horseback riding therapies on emotion and brain activation in patients with cerebral palsy.

[Purpose] The purpose of this study was to determine the effects of assisted aquatic movement and horseback riding therapies on emotion and brain activation in patients with cerebral palsy. [Subjects and Methods] Thirty-two right-handed patients with cerebral palsy (18 male, 14 female) whose ages ranged from 8 to 48 years participated in this experiment. Their cerebral palsy levels ranged from 1 to 3.

Differential frontal theta activity during cognitive and motor tasks.

The present study investigated psychophysiological differences between cognitive and motor tasks. Participants were 16 university students (male[Formula: see text][Formula: see text][Formula: see text]10, female[Formula: see text][Formula: see text][Formula: see text]6) aged between 24 to 31 years (mean[Formula: see text][Formula: see text][Formula: see text]27.6 years, SD[Formula: see text][Formula: see text] [Formula: see text] years).

The frontal executive function in exercise addicts, moderate exercisers, and exercise avoiders.

Background And Objectives: The purpose of this study was to compare the frontal executive functions of exercise addicts, moderate exercisers, and exercise avoiders. We hypothesized that exercise addicts and avoiders would have poorer executive functions compared to moderate exercisers.

Methods: The Korean Exercise Addiction Scale was administrated to recruit participants.

COMPARISON OF ATHLETES WITH AND WITHOUT BURNOUT USING THE STROOP COLOR AND WORD TEST.

The present study compared brain activity of adolescents with or without burnout during their responses to a computerized version of the Stroop Color and Word Test. The Sport Adaptation of the Maslach Burnout Inventory was administered to 460 Korean high school student athletes. Electroencephalographic data were recorded from frontal, central, parietal, and occipital brain regions while these participants were performing the Stroop Color and Word Test.

Changes in baseball batters' brain activity with increased pitch choice.

In baseball, one factor necessary for batters to decide whether to swing or not depends on what type of pitch is thrown. Oftentimes batters will look for their pitch (i.e.

An fMRI study of differences in brain activity among elite, expert, and novice archers at the moment of optimal aiming.

Objective: We investigated brain activity in elite, expert, and novice archers during a simulated archery aiming task to determine whether neural correlates of performance differ by skill level.

Background: Success in shooting sports depends on complex mental routines just before the shot, when the brain prepares to execute the movement.

Methods: During functional magnetic resonance imaging, 40 elite, expert, or novice archers aimed at a simulated 70-meter-distant target and pushed a button when they mentally released the bowstring.

Effects of context on implicit and explicit lexical knowledge: an event-related potential study.

Although much is known about how contextualized and decontextualized learning affects explicit lexical knowledge, how these learning conditions contribute to implicit lexical knowledge remains unclear. To address this problem, Korean high school students were instructed to learn 30 English words by reading meaningful passages (i.e.