Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of to Ionizing Radiation.

The enzyme phosphoribosyl pyrophosphate synthase (PRPS) catalyzes the conversion of ribose 5-phosphate into phosphoribosyl diphosphate; the latter is a precursor of purine and pyrimidine nucleotides. Here, we investigated the function of PRPS from the single-celled green alga in its response to DNA damage from gamma radiation or the alkylating agent LiCl. transcripts were upregulated in cells treated with these agents.