Publications by authors named "Kwami Ketosugbo"
Article Synopsis
- Late alopecia, which is incomplete hair regrowth after chemotherapy or endocrine therapy, affects women's quality of life, leading this study to investigate oral minoxidil as a treatment option.
- The study included 216 patients, primarily women with breast cancer, and found that 74% experienced improvement in hair regrowth after using oral minoxidil for about 3.5 months.
- Results showed significant increases in hair density on both the frontal and occipital areas, indicating that oral minoxidil is well-tolerated and may help cancer survivors with late alopecia.
Background: Photodynamic therapy (PDT) with topical δ-Aminolevulinic acid (ALA) has efficacy in treating basal cell carcinoma (BCC) but is limited by incomplete penetration of ALA into the deeper dermis. This prospective open-label pilot trial investigated the safety and efficacy of photosensitizer jet injection for PDT (JI-PDT) for BCC treatment. It was performed with 15 patients (n = 15) with histologically confirmed, untreated, low-risk nodular BCCs at a single institution.
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- Immune-related cutaneous adverse events (ircAEs) affect over 50% of patients on checkpoint inhibitors, yet their mechanisms remain unclear.
- A study examined 200 patients (139 with ircAEs and 61 controls) to identify clinical presentations and cytokine responses, leading to the discovery of eight different ircAE phenotypes, such as pruritus and eczema, each involving immune cell infiltration.
- Analysis showed unique cytokine profiles related to specific phenotypes, revealing potential treatment strategies that could involve targeted therapies or corticosteroids for effective management of these adverse events.
Immune-related cutaneous adverse events due to checkpoint inhibitors.
Ann Allergy Asthma Immunol
June 2021
Objective: To familiarize the reader with the most common cutaneous adverse events with immune checkpoint inhibitors (CPIs) and their grading and treatment.
Data Sources: Recent research articles, relevant review articles, and case series/reports in English from the PubMed database mostly, from 2010 onward.
Study Selections: Most data are from retrospective studies and case series.
Apoptosis is crucial during the morphogenesis of most organs and tissues, and is utilized for tissues to achieve their proper size, shape and patterning. Many signaling pathways contribute to the precise regulation of apoptosis. Here we show that Jun N-terminal Kinase (JNK) activity contributes to the coordinated removal of interommatidial cells via apoptosis in the Drosophila pupal retina.
View Article and Find Full Text PDFUbiquitination is a crucial post-translational modification that can target proteins for degradation. The E3 ubiquitin ligases are responsible for recognizing substrate proteins for ubiquitination, hence providing specificity to the process of protein degradation. Here, we describe a genetic modifier screen that identified E3 ligases that modified the rough-eye phenotype generated by expression of cindrRNAi transgenes during Drosophila eye development.
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