Thyrotoxic periodic paralysis: A retrospective, observational study from India.

Background & Objectives: Thyrotoxic periodic paralysis (TPP) is an endocrine emergency presenting with acute-onset flaccid paralysis in a patient having thyrotoxicosis accompanied by hypokalaemia. This study was conducted to evaluate the clinical profile of patients with TPP presenting to three centres in India.

Methods: This retrospective, observational study was conducted at three tertiary care Armed Forces medical centres, located at Lucknow, Kolkata and Delhi.

The good, the bad, and the ugly facets of insulin resistance.

Insulin is a potent anabolic hormone, and binding to its receptor activates downstream intracellular signaling pathways that regulate the nutrient metabolism, fluid homeostasis, growth, ionic transport, maintenance of vascular tone, and other functions. Insulin resistance (IR) is a condition characterized by subnormal cellular response to physiological levels of insulin. The IR is divided into three types (prereceptor, receptor, and postreceptor) based on the site of pathology.

Levothyroxine Dosing after Delivery in Women Diagnosed with Hypothyroidism During Pregnancy-A Retrospective, Observational Study.

Background: Pregnancy leads to profound alteration in thyroid function and dysthyroidism contributes to adverse pregnancy outcomes. Though the management of hypothyroidism during pregnancy is highlighted, the same is often neglected during postpartum. We have evaluated the postpartum levothyroxine (LT4) dose change in patients with new onset hypothyroidism.

Seven Sinful Sisters: Seven Smart Solutions to Stop Diabetes.

This article describes a Seven Sinful Sisters and Smart Solutions (FIVE S) concept, which lists seven contributory factors of diabetes, and seven potential solutions to help prevent its spread. The Seven Sinful Sisters include Sugar, Salt, Saturated fat, Spirits (alcohol), Sitting time (sedentary life style), Steroids (including other drugs) and Stress. Seven Smart salutogenic Solutions are use of Self-restraint, Small size portions, Spices (nutrition -based remedies, including sugar and salt substitutes), Slimnastics (a synonym for aerobic exercise), high Spirit (a positive attitude), health Sleep/Siesta, and enjoyment of Sunday (or Stress management).

Association of Vitamin D and Parathyroid Hormone with Insulin Sensitivity, Beta Cell Function and Gestational Diabetes in Pregnancy: A Cross-Sectional, Observational Study.

Introduction: Vitamin D (25OHD) and parathyroid hormone (PTH) are associated with dysglycemia, and we investigated them in gestational diabetes mellitus (GDM).

Methods: In this cross-sectional, observational study, we included 75 pregnant women between 24 and 28 weeks of gestation. A fasting venous sample was collected for plasma glucose (FPG), insulin, PTH and 25OHD.

A randomized, controlled trial comparing the metformin, oral contraceptive pills and their combination in patients with polycystic ovarian syndrome.

Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by insulin resistance (IR) and hormonal dysfunction. We conducted a randomized, controlled trial comparing the effects of metformin, oral contraceptive pills (OCP) and their combination in PCOS.

Materials And Methods: We randomized 90 newly diagnosed PCOS (age 18-40 year, symptom duration >6 months) patients into three groups (Group 1-Metformin, Group 2-OCP, and Group 3- Metformin + OCP) in this prospective study.

Profile of pulmonary embolism in service personnel posted at high altitude area.

Background: We evaluated the clinical presentation and risk factors of pulmonary embolism (PE) in soldiers posted at high altitude areas (HAA).

Methods: We conducted a retrospective analysis of all cases of PE presented to us between March 2011 and Aug 2014. The patients were serving at an altitude between 10,000 and 22,000ft above sea level and PE was diagnosed using the pulmonary CT angiography.

A Prospective, Observational Study of Osteoporosis in Men.

Context: The number of men afflicted with osteoporosis is unknown.

Aims: This study aims to determine the prevalence of osteoporosis in men.

Settings And Design: This was a prospective, observational study.

Occult metabolic bone disease in chronic pancreatitis.

Background: Chronic pancreatitis (CP) leads to malabsorption and metabolic bone disease (MBD). Alcoholic CP (ACP) and tropical CP (TCP) are the two common types of CP.

Objective: We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP.

Mortality audit of medical patients at armed forces hospitals.

The mortality statistics of the medical patients at our tertiary care hospitals are sparse and lacking. We studied the mortality characteristics of the patients admitted to medical wards and intensive care unit at two hospitals based on the available fatal documents. Our objectives include analysis of the cause of death, duration of stay and presence of sepsis.

Incidence of parathyroid disorders in Indian adult male population: A 25-year follow-up study.

Context And Objective: Detailed information on the epidemiology of parathyroid disorders in India is lacking. Most of the available data pertain to primary hyperparathyroidism (PHPT) rather than the overall burden of parathyroid disorders. We studied the incidence of parathyroid disorders in a cohort of service personnel followed for a long duration.

Etiopathological differentiation of diabetes mellitus in lean, young adults.

Objective: Classification of diabetes mellitus (DM) into type 1 or type 2 is difficult in lean, young individuals. We studied the β-cell function, insulin resistance (IR) and autoimmunity in young patients with recent onset DM.

Methods: In this cross-sectional study, we included patients (age below 35 years) with recent onset DM (<6 months) and normal body weight for evaluation.

Profile of infections in renal transplant recipients from India.

Background: Infectious disorders are a major cause of concern in renal transplant recipients (RTRs) leading to considerable morbidity and mortality. We studied the profile and outcomes of infectious disorders in a cohort of RTR.

Materials And Methods: In this prospective, observational study, we evaluated all RTR who presented with the features of infection.

Prevalence of Multidrug-resistant, Extensively Drug-resistant, and Pandrug-resistant from a Tertiary Level Intensive Care Unit.

Background: Infection by is common in the Intensive Care Unit (ICU), leading to increased morbidity and mortality. The organism is classified into various phenotypes based on the drug resistance pattern, namely, drug-resistant (DR), multi-DR (MDR), extensively DR (XDR), and pan-DR (PDR). We aim to study the incidence of phenotypes in a tertiary level ICU.

Prevalence of hypothalamo pituitary dysfunction in patients of traumatic brain injury.

Background: Traumatic brain injury (TBI) is common in young soldiers of armed forces leading to significant morbidity and mortality. We studied the prevalence of hypopituitarism following TBI and its association with trauma severity.

Materials And Methods: We conducted a 12-month prospective study of 56 TBI patients for the presence of hormonal dysfunction.